Papers - KITAMURA Kazuo
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活動性潰瘍性大腸炎の入院治療に伴う合併症に関する検討 Reviewed
芦塚伸也、三宮一朗、増田稔、三木吾郎、星子新理、松本英丈、中島孝治、稲津東彦、北村和雄
日本消化器病学会雑誌 111 ( suppl-2 ) 888 - 888 2014
Publishing type：Research paper (scientific journal)
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一般住民におけるアドレノメデュリンとナトリウム利尿ペプチドの血中レベルと慢性腎臓病発症 Reviewed
加藤丈司、桑迫健二、北村和雄
日本内分泌学会雑誌 90 ( 2 ) 751 - 751 2014
Publishing type：Research paper (scientific journal)
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ビッグアンジオテンシン-25 : ヒト尿中の主要なアンジオテンシン関連ペプチド Reviewed
永田さやか、北村和雄
最新医学 69 ( 11月増刊 ) 2276 - 2286 2014
Publishing type：Research paper (scientific journal)
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Long-term survival of patients with IgA nephropathy after dialysis therapy. Reviewed
Komatsu H, Kikuchi M, Nakagawa H, Fukuda A, Iwakiri T, Toida T, Sato Y, Kitamura K, Fujimoto S
Kidney Blood Press Res 37 ( 6 ) 649 - 656 2013.12
Language：English Publishing type：Research paper (scientific journal)
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Big angiotensin-25: A novel glycosylated angiotensin-related peptide isolated from human urine. Reviewed
Nagata S, Hatakeyama K, Asami M, Tokashiki M, Hibino H, Nishiuchi Y, Kuwasako K, Kato J, Asada Y, Kitamura K
Biochem Biophys Res Commun 441 ( 4 ) 757 - 762 2013.11
Language：English Publishing type：Research paper (scientific journal)
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Adrenomedullin as a potential therapeutic agent for inflammatory bowel disease Reviewed
Ashizuka S., Inatsu H., Inagaki-Ohara K., Kita T., Kitamura K.
Current Protein and Peptide Science 14 ( 4 ) 246 - 255 2013.11
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Current Protein and Peptide Science
Adrenomedullin (AM) was originally isolated from human pheochromocytoma as a biologically active peptide with potent vasodilating action but is now known to exert a wide range of physiological effects, including cardiovascular protection, neovascularization, and apoptosis suppression. A variety of tissues, including the gastrointestinal tract, have been shown to constitutively produce AM. Pro-inflammatory cytokines, such as tumor necrosis factor-α and interleukin-1, and lipopolysaccharides, induce the production and secretion of AM. Conversely, AM induces the downregulation of inflammatory cytokines in cultured cells. Furthermore, AM downregulates inflammatory processes in a variety of different colitis models, including acetic acid-induced colitis and dextran sulfate sodium-induced colitis. AM exerts antiinflammatory and antibacterial effects and stimulates mucosal regeneration for the maintenance of the colonic epithelial barrier. Here, we describe the first use of AM to treat patients with refractory ulcerative colitis. The results strongly suggest that AM has potential as a new therapeutic agent for the treatment of refractory ulcerative colitis. © 2013 Bentham Science Publishers.
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Gender difference in relationship between body mass index and development of chronic kidney disease Reviewed
Komura H, Nomura I, Kitamura K, Kuwasako K, Kato J
BMC Res Notes 13 463 - 463 2013.11
Language：English Publishing type：Research paper (scientific journal)
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Efficacy of alogliptin, a dipeptidyl peptidase-4 inhibitor, on glucose parameters, the activity of the advanced glycation end product (AGE) - receptor for AGE (RAGE) axis and albuminuria in Japanese type 2 diabetes. Reviewed
Sakata K, Hayakawa M, Yano Y, Tamaki N, Yokota N, Eto T, Watanabe R, Hirayama N, Matsuo T, Kuroki K, Sagara S, Mishima O, Koga M, Nagata N, Nishino Y, Kitamura K, Kario K, Takeuchi M, Yamagishi S
Diabetes Metab Res Rev 29 ( 8 ) 624 - 630 2013.11
Language：English Publishing type：Research paper (scientific journal)
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ストローマからみた心血管病「ストローマをターゲットとした心血管病の治療」 Reviewed
鶴田敏博、北村和雄
循環器内科 (Cardioangiology) 74 125 - 131 2013.8
Publishing type：Research paper (scientific journal)
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ストローマからみた心血管病 序文 Reviewed
北村和雄、鶴田敏博
循環器内科 (Cardioangiology) 74 123 - 124 2013.8
Publishing type：Research paper (scientific journal)
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Functions of third extracellular loop and helix 8 of Family B GPCRs complexed with RAMPs and characteristics of their receptor trafficking. Reviewed
Curr Protein Pept Sci
Curr Protein Pept Sci 14 ( 5 ) 416 - 428 2013.8
Language：English Publishing type：Research paper (scientific journal)
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Disruption of cerebellar microzonal organization in GluD2 (Glurδ2) knockout mouse Reviewed
Hashizume M., Miyazaki T., Sakimura K., Watanabe M., Kitamura K., Kano M.
Frontiers in Neural Circuits 7 ( JUL ) 130 2013.7
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Frontiers in Neural Circuits
Cerebellar cortex has an elaborate rostrocaudal organization comprised of numerous microzones. Purkinje cells (PCs) in the same microzone show synchronous activity of complex spikes (CSs) evoked by excitatory inputs from climbing fibers (CFs) that arise from neurons in the inferior olive (IO). The synchronous CS activity is considered to depend on electrical coupling among IO neurons and anatomical organization of the olivo-cerebellar projection. To determine how the CF-PC wiring contributes to the formation of microzone, we examined the synchronous CS activities between neighboring PCs in the glutamate receptor δ2 knockout (GluD2 KO) mouse in which exuberant surplus CFs make ectopic innervations onto distal dendrites of PCs. We performed in vivo two-photon calcium imaging for PC populations to detect CF inputs. Neighboring PCs in GluD2 KO mice showed higher synchrony of calcium transients than those in wild-type (control) mice. Moreover, the synchrony in GluD2 KO mice hardly declined with mediolateral separation between PCs up to ~200 μm, which was in marked contrast to the falloff of the synchrony in control mice. The enhanced synchrony was only partially affected by the blockade of gap junctional coupling. On the other hand, transverse CF collaterals in GluD2 KO mice extended beyond the border of microzone and formed locally clustered ectopic synapses onto dendrites of neighboring PCs. Furthermore, PCs in GluD2 KO mice exhibited clustered firing (Cf), the characteristic CF response that was not found in PCs of wild-type mice. Importantly, Cf was often associated with localized calcium transients in distal dendrites of PCs, which are likely to contribute to the enhanced synchrony of calcium signals in GluD2 KO mice. Thus, our results indicate that CF signals in GluD2 KO mice propagate across multiple microzones, and that proper formation of longitudinal olivo-cerebellar projection is essential for the spatiotemporal organization of CS activity in the cerebellum. © 2013 Hashizume, Miyazaki, Sakimura, Watanabe, Kitamura and Kano.
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Validation of a newly proposed histopathological classification in Japanese patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis. Reviewed
Iwakiri T, Fujimoto S, Kitagawa K, Furuichi K, Yamahana J, Matsuura Y, Yamashita A, Uezono S, Shimao Y, Hisanaga S, Tokura T, Wada T, Kitamura K, Asada Y
BMC Nephrol 14 ( 1 ) 125 - 125 2013.6
Language：English Publishing type：Research paper (scientific journal)
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Reduced fractional shortening of right ventricular outflow tract is associated with adverse outcomes in patients with left ventricular dysfunction. Reviewed
Yamaguchi M, Tsuruda T, Watanabe Y, Onitsuka H, Furukawa K, Ideguchi T, Kawagoe J, Ishikawa T, Kato J, Takenaga M, Kitamura K
Cardiovasc Ultrasound 11 ( 1 ) 19 - 19 2013.6
Language：English Publishing type：Research paper (scientific journal)
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Autocrine effects of neuromedin B stimulate the proliferation of rat primary osteoblasts. Reviewed
Saito H, Nakamachi T, Inoue K, Ikeda R, Kitamura K, Minamino N, Shioda S, Miyata A
J Endocrinol 217 ( 2 ) 141 - 150 2013.4
Language：English Publishing type：Research paper (scientific journal)
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Hepatocyte growth factor activator inhibitor type 1 is a suppressor of intestinal tumorigenesis Reviewed
Hoshiko S., Kawaguchi M., Fukushima T., Haruyama Y., Yorita K., Tanaka H., Seiki M., Inatsu H., Kitamura K., Kataoka H.
Cancer Research 73 ( 8 ) 2659 - 2670 2013.4
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Cancer Research
Hepatocyte growth factor activator inhibitor type 1 (HAI-1/SPINT1) is a membrane-bound serine protease inhibitor expressed on the surface of epithelial cells. Although HAI-1/SPINT1 is abundantly expressed in the intestinal epithelium, its role in intestinal tumorigenesis is not known. In this study, we investigated the role of Hai-1/Spint1 in intestinal tumorigenesis using mouse models. The membranous Hai-1/Spint1 immunoreactivity was decreased in murine ApcMin/+ tumors and also in carcinogen (azoxymethane treatment followed by dextran sodium sulfate administration)-induced colon tumors compared with the adjacent non-neoplastic epithelium. The decreased immunoreactivity appeared to be due to sheddase activity of membrane-type 1 matrix metalloprotease. Then, we examined the effect of intestine-specific deletion of Spint1 gene on ApcMin/+ mice. The loss of Hai-1/Spint1 significantly accelerated tumor formation in ApcMin/+ mice and shortened their survival periods. Activation of HGF was enhanced in Hai-1/Spint1-deficient ApcMin/+ intestine. Gene expression profiling revealed upregulation of the Wnt/b-catenin signaling circuit, claudin-2 expression, and angiogenesis not only in tumor tissue but also in the background mucosa without macroscopic tumors in Hai-1/Spint1-deficient ApcMin/+ intestine. Intestinal deletion of Spint1 also enhanced the susceptibility to carcinogen-induced colon tumorigenicity of wild-type Apc mice. Our findings suggest that HAI-1/SPINT1 has a crucial role in suppressing intestinal tumorigenesis, which implies a novel link between epithelial cell surface serine protease inhibitors and protection from carcinogenic stimuli. © 2013 American Association for Cancer Research.
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Organized thrombus in aspirated coronary materials can predict in-hospital mortality of patients with acute myocardial infarction. Reviewed
Nishihira K, Hatakeyama K, Shibata Y, Kitamura K, Asada Y
Circ J 77 ( 5 ) 1275 - 1280 2013.2
Language：English Publishing type：Research paper (scientific journal)
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Adrenomedullin: A novel therapy for intractable ulcerative colitis. Reviewed
Ashizuka S, Kita T, Inatsu H, Kitamura K
Inflamm Bowel Dis 19 ( 2 ) 26 - 27 2013.2
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1002/ibd.22891.
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Electrocardiographic assessment of incident atrial fibrillation in hemodialysis patients. Reviewed
Nishi K, Fujimoto S, Hisanaga S, Ogawa O, Kitamura K
Ther Apher Dial 17 ( 1 ) 16 - 23 2013.2
Language：English Publishing type：Research paper (scientific journal)
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Hemodynamic and hormonal changes to dual renin-angiotensin system inhibition in experimental hypertension. Reviewed
Moniwa N, Varagic J, Ahmad S, VonCannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM
Hypertension 61 ( 2 ) 417 - 424 2013.2
Language：English Publishing type：Research paper (scientific journal)