Papers - KITAMURA Kazuo
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食塩摂取量の変化に伴う血中と組織中プロアンジオテンシン-12(proang-12)およびレニン・アンジオテンシン(RA)系因子の変化 Reviewed
永田さやか、加藤丈司、北村和雄
日本内分泌学会雑誌 85 ( 1 ) 374 - 374 2009
Publishing type：Research paper (scientific journal)
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地域住民における血中アルドステロンとbody mass index(BMI)およびインスリン値との関連 Reviewed
野村郁夫、加藤丈司、北村和雄
日本内分泌学会雑誌 85 ( 2 ) 716 - 716 2009
Publishing type：Research paper (scientific journal)
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話題のホルモン・受容体・酵素: 最近の知見から アドレノメデュリン(AM), PAMPとその受容体 Reviewed
北村和雄
Heart View 13 ( 12 ) 69 - 75 2009
Publishing type：Research paper (scientific journal)
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アドレノメデュリンの発見 Reviewed
北村和雄
日本臨牀 67 ( 6 ) 67 - 72 2009
Publishing type：Research paper (scientific journal)
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大動脈瘤と炎症細胞(マスト細胞とマクロファージ) Reviewed
鶴田敏博、北村和雄
血管医学 10 ( 3 ) 221 - 229 2009
Publishing type：Research paper (scientific journal)
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第16回 腹部大動脈瘤の発症・進展とアドレノメデュリン Reviewed
鶴田敏博、北村和雄
Vascular Medicine 5 ( 3 ) 166 - 172 2009
Publishing type：Research paper (scientific journal)
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直腸MALTリンパ腫疑診症例から直腸炎型潰瘍性大腸炎へと変化した一例 Reviewed
中島孝治、彦坂ともみ、星子新理、松本英丈、芦塚伸也、早稲田文子、押川勝太郎、稲津東彦、北村和雄、丸塚浩助、堺雅彦
日本消化器病学会雑誌 106 ( suppl-1.2 ) 484 - 484 2009
Publishing type：Research paper (scientific journal)
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術前S-1+CDDP療法が奏効した進行胃癌の1例 Reviewed
中島孝治、彦坂ともみ、星子新理、松本英丈、芦塚伸也、早稲田文子、押川勝太郎、稲津東彦、北村和雄、河野文彰、関屋亮、鬼塚敏男、片岡寛章
日本消化器病学会雑誌 106 ( suppl-2.2 ) 790 - 790 2009
Publishing type：Research paper (scientific journal)
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盲腸, 上行結腸への浸潤伸展がみられた虫垂杯細胞カルチノイドの一例 Reviewed
星子新理、彦坂ともみ、早稲田文子、松本英丈、中島孝治、芦塚伸也、押川勝太郎、稲津東彦、北村和雄、日高秀樹、佛坂正幸、千々岩一男、梅北佳子、田中弘之、片岡寛章
日本消化器病学会雑誌 106 ( suppl-2.2 ) 402 - 402 2009
Publishing type：Research paper (scientific journal)
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5-FU/CDDP併用化学放射線療法にてCRが得られた進行期食道腺癌の1例 Reviewed
三木吾郎、押川勝太郎、芦塚伸也、中島孝治、早稲田文子、大塚正晃、彦坂ともみ、稲津東彦、北村和雄、田井博、鶴身小都絵
日本消化器病学会雑誌 106 ( suppl-2.2 ) 762 - 762 2009
Publishing type：Research paper (scientific journal)
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小腸内視鏡で確認しえた心臓原発平滑筋肉腫多発消化管転移の一例 Reviewed
原口大、彦坂ともみ、星子新理、松本英丈、早稲田文子、芦塚伸也、中島孝治、押川勝太郎、稲津東彦、北村和雄、松田俊太郎、丸塚浩助
日本消化器病学会雑誌 106 ( suppl-2.2 ) 815 - 815 2009
Publishing type：Research paper (scientific journal)
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原因候補遺伝子 アドレノメデュリン遺伝子 Reviewed
桑迫健二、加藤丈司、北村和雄
日本臨牀 67 ( 6 ) 400 - 404 2009
Publishing type：Research paper (scientific journal)
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JATOS Study Group
Hypertension Research 31 ( 12 ) 2115 - 2127 2008.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Hypertension Research
The benefits of lowering a systolic blood pressure below 140 mmHg in elderly hypertension remain controversial. This study is a prospective, randomized, open-label study with blinded assessment of endpoints to compare the 2-year effect of strict treatment to maintain systolic blood pressure below 140 mmHg with that of mild treatment to maintain systolic blood pressure below 160 but at or above 140 mmHg in elderly hypertensive patients. Patients with essential hypertension (65-85 years old, with a pretreatment systolic blood pressure of above 160 mmHg) were randomly assigned to receive strict treatment (n=2,212) or mild treatment (n=2,206). The baseline drug was efonidipine hydrochloride, a long-acting calcium antagonist. The primary endpoint was the combined incidence of cardiovascular disease and renal failure, and the secondary endpoints were total deaths and any safety problems. Although final blood pressures (systolic/diastolic) were significantly lower in the strict-treatment group compared with the mild-treatment group (135.9/ 74.8 vs. 145.6/78.1 mmHg; p<0.001), the incidence of the primary endpoint was similar in the two groups (86 patients in each group; p=0.99). Total deaths were 54 in the strict-treatment group vs. 42 in the mild-treatment group (p=0.22), and treatment was withdrawn because of adverse events in 36 patients in each group (p=0.99). An interaction between age and treatment for the primary endpoints (p=0.03) was seen. Complex clinical features associated with aging seem to have obscured the difference in effect between the two treatments. Further studies are needed to assess the optimal treatment strategy for hypertension in the elderly.
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Therapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits. "jointly worked" Reviewed
Okura T, Marutsuka K, Hamada H, Sekimoto T, Fukushima T, Asada Y, Kitamura K, Chosa E
Arthritis Res Ther 10 ( 6 ) R133 2008.11
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1186/ar2550.
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Functions of the extracellular histidine residues of receptor activity-modifying proteins vary within adrenomedullin receptors. "jointly worked" Reviewed
Kuwasako K, Kitamura K, Nagata S, Kato J
Biochem Biophys Res Commun 377 ( 1 ) 109 - 113 2008.10
Language：English Publishing type：Research paper (scientific journal)
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Long-term therapy with nifedine-CR improves arterio-sclerosis related markers in patients with untreated essential hypertension. "jointly worked" Reviewed
Kita T, Tokashiki M, Kitamura K
The Open Hypertension Journal 1 1 - 6 2008.9
Language：English Publishing type：Research paper (scientific journal)
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Elevated osteoprotegerin levels predict cardiovascular events in new hemodialysis patients. "jointly worked" Reviewed
Nishiura R, Fujimoto S, Sato Y, Yamada K, Hisanaga S, Hara S, Nakao H, Kitamura K
American Journal of Nephrology 29 ( 3 ) 257 - 263 2008.9
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1159/000157629
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Serotonin induces vasoconstriction of smooth muscle cell-rich neointima through 5-hydroxytryptamine2A receptor in rabbit femoral arteries. "jointly worked" Reviewed
Nishihira K, Yamashita A, Tanaka N, Moriguchi-Goto S, Imamura T, Ishida T, Kawashima S, Yamamoto R, Kitamura K, Asada Y
J Thromb Haemost 6 ( 7 ) 1207 - 1214 2008.7
Language：English Publishing type：Research paper (scientific journal)
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Adrenomedullin 2/intermedin-like immunoreactivity in the hypothalamus and brainstem of rats. "jointly worked" Reviewed
Hashimoto H, Kitamura K, Kawasaki M, Saito T, Suzuki H, Otsubo H, Ohbuchi T, Yokoyama T, Fujihara H, Takei Y, Ueta Y
Auton Neurosci 139 ( 1-2 ) 46 - 54 2008.5
Language：English Publishing type：Research paper (scientific journal)
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Effect of tonsillectomy plus steroid pulse therapy on clinical remission of IgA nephropathy: a controlled study. "jointly worked" Reviewed
Komatsu H, Fujimoto S, Hara S, Sato Y, Yamada K, Kitamura K
Clin J Am Soc Nephrol 3 ( 5 ) 1301 - 1307 2008.5
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.2215/CJN.00310108