Papers - KITAMURA Kazuo
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Immunoreactive endothelin in rat kidney inner medulla marked decrease in spontaneously hypertensive rats Reviewed
K Kitamura 1, T Tanaka, J Kato, T Ogawa, T Eto, K Tanaka
Biochem Biophys Res Commun 14 ( 162（1） ) 38 - 44 1989.7
Publishing type：Research paper (scientific journal)
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Regional distribution of immunoreactive endothelin in porcine tissue abundance in inner medulla of kidney Reviewed
K Kitamura 1, T Tanaka, J Kato, T Eto, K Tanaka
Biochem Biophys Res Commun 30 ( 161（1） ) 348 - 352 1989.5
Publishing type：Research paper (scientific journal)
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Catalytic site of rat liver and bovine heart fructose-6-phosphate,2-kinasefructose-2,6-bisphosphatase Reviewed
K Kitamura , K Uyeda, F C Hartman, K Kangawa, H Matsuo
J Biol Chem 15 ( 264（11） ) 6344 - 6348 1989.4
Publishing type：Research paper (scientific journal)
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Phosphorylation of myocardial fructose-6-phosphate,2-kinase: fructose-2,6-bisphosphatase by cAMP-dependent protein kinase and protein kinase C. Activation by phosphorylation and amino acid sequences of the phosphorylation sites Reviewed
K Kitamura , K Kangawa, H Matsuo, K Uyeda
J Biol Chem 15 ( 263（32） ) 16796 - 16801 1988.11
Publishing type：Research paper (scientific journal)
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Isozymes of fructose 6-phosphate,2-kinasefructose-2,6-bisphosphatase in rat and bovine heart, liver, and skeletal muscle Reviewed
M Taniyama , K Kitamura, H Thomas, J W Lawson, K Uyeda
Biochem Biophys Res Commun 30 ( 157（3） ) 949 - 954 1988.10
Publishing type：Research paper (scientific journal)
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Immunoreactive neuromedin B and neuromedin C distribution and molecular heterogeneity in rat and human tissue extracts Reviewed
A Sakamoto , K Kitamura, Y Haraguchi, T Yoshida, K Tanaka
Am J Gastroenterol 82 ( 10 ) 1035 - 1041 1987.10
Publishing type：Research paper (scientific journal)
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Plasma concentration of human atrial natriuretic polypeptide in patients with impaired renal function Reviewed
Y Yamamoto, T Higa, K Kitamura, K Tanaka, K Kangawa, H Matsuo
Clin Nephrol 27 ( 2 ) 84 - 86 1987.2
Publishing type：Research paper (scientific journal)
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The mechanism of activation of heart fructose 6-phosphate,2-kinasefructose-2,6-bisphosphatase Reviewed
K Kitamura, K Uyeda
J Biol Chem 15 ( 262（2） ) 679 - 681 1987.1
Publishing type：Research paper (scientific journal)
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Plasma concentration of atrial natriuretic polypeptide in chronic hemodialysis patients Reviewed
Y Yamamoto, T Higa, K Kitamura, K Tanaka, K Kangawa, H Matsuo
Clin Nephrol 27 ( 2 ) 84 - 6 1987
Publishing type：Research paper (scientific journal)
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HIGA TOSHINOBU, KITAMURA KAZUO, MIYATA ATSURO, KANGAWA KENJI, MATSUO HISAYUKI, TANAKA KENJIRO
Japanese Circulation Journal 49 ( 9 ) 973 - 979 1985
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japanese Circulation Society
The cardiac content and plasma concentration of atrial natriuretic polypeptide (ANP) in hypertensive rats were measured by using radioimmunoassay for ANP. The animals used in this study were young (5-week-old) and adult (12- to 14-week-old) spontaneously hypertensive rats (SHR), strokeprone SHR (SHR-SP) and normotensive control Wistar-Kyoto rats (WKY). Most immunoreactive ANP in the cardiac extract of the hypertensive rats (both SHR and SHR-SP) was found to be predominantly γ-form as well as that of WKY. Cardiac ANP content in adult SHR and SHR-SP was significantly lower than in adult WKY (p < 0.01), although there were no differences among three groups in young rats. Similar tendencies were also observed for plasma ANP concentration. The level of plasma in adult hypertensive rats was significantly lower or tended to be lower than in adult normotensive rats. Furthermore, a high negative correlation was present between blood pressure and cardiac ANP content (r=-0.748, p <0.01) and between blood pressure and plasma ANP concentration (r=-0.608, p < 0.01) in all adult rats but there were no such relationships in young rats. The present study suggests that atrial natriuretic polypeptide may contribute to the pathogenesis or maintenance of high blood pressure in the genetic hypertensive rats.
DOI： 10.1253/jcj.49.973
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Plasma concentration of atrial natriuretic polypeptide in chronic hemodialysis patients Reviewed
Y Yamamoto, T Higa, K Kitamura, K Tanaka, K Kangawa, H Matsuo
Regul Pept Suppl 4 110 - 112 1985
Publishing type：Research paper (scientific journal)
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Regional distribution of β-neo-endorphin in rat brain and pituitary Reviewed
Kitamura K., Minamino N., Hayashi Y., Kangawa K., Matsuo H.
Biochemical and Biophysical Research Communications 109 ( 3 ) 966 - 974 1982.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Biochemical and Biophysical Research Communications
A highly specific and sensitive radioimmunoassay for β-neo-endorphin was developed, by using an antiserum against β-neo-endorphin. With this assay, the regional distribution of β-neo-endorphin was determined in rat brain and pituitary, and compared with that of α-neo-endorphin, which was assayed in the same samples. β-Neo-endorphin was found to be concentrated in the pituitary, especially in the posterior lobe, like α-neo-endorphin. β-Neo-endorphin was also widely distributed in brain, but in a different manner than α-neo-endorphin. Remarkable differences were observed in hippocampus, striatum and cortex, where α-neo-endorphin was found to predominate over β-neo-endorphin. The fact suggests that both peptides, although they are structurally related, possess different physiological functions. © 1982.
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腸管に存在するエンケフアリン関連ペプチド Reviewed
北村和雄、松尾寿之
日本内分泌学会雑誌 秋季大会抄録号 58 ( suppl-1 ) 1180 - 1180 1982
Publishing type：Research paper (scientific journal)
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Regional distribution of α-neo-endorphin in rat brain and pituitary Reviewed
Minamino N., Kitamura K., Hayashi Y., Kangawa K., Matsuo H.
Biochemical and Biophysical Research Communications 102 ( 1 ) 226 - 234 1981.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Biochemical and Biophysical Research Communications
α-Neo-endorphin was isolated as the first form of "big" Leu-enkephalin and its complete amino acid sequence has recently been established. Using an antiserum raised against synthetic α-neo-endorphin, a highly sentitive and specific radioimmunoassay was developed. The antiserum practically possesses no cross-reactivity to Leu-enkephalin, dynorphin[1-13] and PH-8P, and very little to β-neo-endorphin. Distribution of α-neo-endorphin has been determined in rat brain and pituitary by the use of the highly specific antiserum. The highest concentration was observed at posterior lobe of pituitary. Furthermore, immunoreactive α-neo-endorphin was characterized by gel-filtration and high performance liquid chromatography, and shown to be identical with authentic α-neo-endorphin. © 1981.
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REGIONAL DISTRIBUTION OF IMMUNOREACTIVE BIG LEU-ENKEPHALINS IN BRAIN AND PITUITARY Reviewed
N.MinaminoY.HayashiK.KitamuraH.MatsuoK.Kangawa
Proceedings of the International Narcotic Research Conference (Satellite Symposium of the 8th International Congress of Pharmacology) Held in Kyoto 26 ( 30 ) 160 - 162 1981.7
Publishing type：Research paper (scientific journal)