Papers - KITAMURA Kazuo
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Adrenomedullin a protective factor for blood vessels Reviewed
加藤 丈司,鶴田 敏博,北 俊弘,北村 和雄,江藤 胤尚
Arterioscler Thromb Vasc Biol 25 2480 - 2487 2005.12
Language：English Publishing type：Research paper (scientific journal)
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Adrenomedullin release in the rat mesenteric resistance artery Reviewed
Akiyama S,Hobara N,Naruo N,Hashida S,北村 和雄,江藤 胤尚,Kawasaki H
Peptides 26 2222 - 2230 2005.11
Language：English Publishing type：Research paper (scientific journal)
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Cao Y.N., Kuwasako K., Kato J., Nishihira K., Asada Y., Eto T., Kitamura K.
FEBS Letters 579 ( 22 ) 4997 - 5001 2005.9
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：FEBS Letters
We developed a transgenic (Tg) rat model that overexpresses human proadrenomedullin N-terminal 20 peptide (PAMP) only and then compared the effects of unilateral nephrectomy followed by a high salt diet for five weeks in Tg and wild-type rats. We found that systolic blood pressure was significantly lower in Tg UNX rats and cardiac hypertrophy and myocardial fibrosis was also attenuated in Tg rats. Evaluation of gene expression showed suppression of cardiac local renin-angiotensin system (RAS) in Tg rat. These results suggest that in addition to reducing blood pressure, PAMP suppresses cardiac hypertrophy through negative regulation of the local cardiac RAS. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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アドレノメデュリンと血庄調節異常 Reviewed
加藤丈司、北村和雄、江藤胤尚
生活習慣病の最前線. Molecular medicine : 分子生物学から臨床へ 42 ( 1 ) 234 - 237 2005.9
Publishing type：Research paper (scientific journal)
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Beyond vasodilation: The antioxidant effect of adrenomedullin in Dahl salt-sensitive rat aorta Reviewed
Cao Y.N., Kuwasako K., Kato J., Yanagita T., Tsuruda T., Kawano J., Nagoshi Y., Chen A.F., Wada A., Suganuma T., Eto T., Kitamura K.
Biochemical and Biophysical Research Communications 332 ( 3 ) 866 - 872 2005.7
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Biochemical and Biophysical Research Communications
We have investigated the antioxidant effect of adrenomedullin (AM) on endothelial function in the Dahl salt-sensitive (DS) rat hypertension model. Dahl salt-resistant (DR) and DS rats were fed an 8% NaCl diet. In addition, the DS rats were subcutaneously infused with either saline or recombinant human AM for 4 weeks. Although systolic blood pressures measured weekly in AM- and saline-infused rats did not significantly differ, aortic O2- levels were significantly (P < 0.01) higher in the latter. Likewise, both endothelial nitric oxide synthase (eNOS) mRNA and protein were significantly higher in saline-infused DS rats. Infusion of AM reduced both O2- and eNOS expression to levels comparable to those seen in DR rats. AM infusion also upregulated the gene expression of guanosine-5′-triphosphate cyclohydrolase I and downregulated the expression of p22phox, suggesting that AM increased the NOS coupling and bioavailability of NO. AM possesses significant antioxidant properties that improve endothelial function. © 2005 Elsevier Inc. All rights reserved.
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Angiotensin II stimulates cardiac adrenomedullin production and causes accumulation of mature adrenomedullin independently of hemodynamic stress in vivo Reviewed
鬼塚 久充,今村 卓郎,山家 純一,桑迫 健二,北村 和雄,江藤 胤尚
Horm Metab Res 37 281 - 285 2005.5
Language：English Publishing type：Research paper (scientific journal)
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Tsuruda T., Kato J., Hatakeyama K., Masuyama H., Cao Y.N., Imamura T., Kitamura K., Asada Y., Eto T.
Cardiovascular Research 65 ( 4 ) 921 - 929 2005.3
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Cardiovascular Research
Objective: The extracellular matrix (ECM) determines the structural integrity of the heart and vasculature, participating in cardiovascular remodeling. We previously reported that adrenomedullin (AM) inhibited cellular proliferation and protein synthesis of cardiac fibroblasts; however, the precise mechanisms of AM actions as an antifibrotic factor remain unknown. The purpose of this study was to examine the biological actions of AM against the profibrotic factor angiotensin II (Ang II) in coronary adventitia. Methods and results: Rats with hypertension induced by Ang II infusion were administered 0.06 μg/kg/min recombinant human AM subcutaneously for 14 days. The AM infusion significantly (p<0.05) reduced the Ang II-induced increase of coronary adventitial fibroblasts expressing Ki-67 and α-smooth muscle actin (α-SMA) in the left ventricle, by 65%, and 62%, respectively, without affecting systolic blood pressure, left ventricle/body weight, or cross-sectional area of myocardial fibers. Collagen deposition of coronary arteries was reduced by the AM infusion (-24%, p<0.01), and these effects of AM were accompanied by significant reductions in gene expression of type 1 collagen (-49%, p<0.05) and transforming growth factor-β1 (TGF-β1) (-55%, p<0.01). In cultured cardiac fibroblasts, 10-7 mol/L AM exerted an inhibitory effect on TGF-β1-induced α-SMA expression (p<0.01) that was mimicked by 8-bromo-cAMP and attenuated by the protein kinase A inhibitor H-89. Conclusion: AM decreased Ang II-induced collagen deposition surrounding the coronary arteries, inhibiting myofibroblast differentiation and expressions of ECM-related genes in rats. The present findings further support the biological action of AM as an antifibrotic factor in vascular remodeling. © 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
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アドレノメデュリンの測定と血中濃度All of adrenomedullin (2005). Adrenomedullin assay and its plasma level. Reviewed
加藤丈司、北村和雄
ホルモンと臨牀 53 ( 3 ) 269 - 274 2005.3
Publishing type：Research paper (scientific journal)
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Atrial and brain natriuretic peptides as markers of cardiac load and volume retention in primary aldosteronism Reviewed
加藤 丈司,江藤 琢磨,北村 和雄,江藤 胤尚
Am J Hypertens 18 354 - 357 2005.3
Language：English Publishing type：Research paper (scientific journal)
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心血管作動物質と循環器疾患－最近の話題－ アドレノメデュリンの循環器系における役割 Reviewed
北村和雄
循環器内科 57 ( 2 ) 134 - 140 2005.2
Publishing type：Research paper (scientific journal)
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Tsuruda T., Kato J., Matsui E., Hatakeyama K., Masuyama H., Imamura T., Kitamura K., Asada Y., Eto T.
European Journal of Pharmacology 508 ( 1-3 ) 201 - 204 2005.1
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：European Journal of Pharmacology
Producing components of the extracellular matrix, the vascular adventitia has been recognized as an important modulator of the vascular remodeling process, which determines the vessel architecture. In this study, we examined the effect of the vasodilator peptide adrenomedullin on vascular remodeling induced by balloon injury of rat carotid arteries. Endothelial denudation with wall stretch by ballooning not only induced neointimal formation accompanied with a reduced ratio of the lumen to vessel area, but also increased the fibroblast number and collagen deposition in the adventitial layer. When compared with the saline infusion, intravenous adrenomedullin infusion at 200 ng/h for 14 days suppressed the neointimal formation (-33%, P=0.033), reversing the ratio of lumen to vessel ratio (P=0.030), without affecting systolic blood pressure. Moreover, the adrenomedullin infusion decreased the number of adventitial fibroblasts (-41%, P<0.001) and the collagen deposition (-36%, P=0.006) in the adventitial layer of the injured artery. In conclusion, the intravenous adrenomedullin infusion effectively attenuates vascular remodeling following the arterial injury via suppression of hyperplasia in the intima and adventitia, suggesting a potential of adrenomedullin as a therapeutic tool against vascular remodeling. © 2004 Elsevier B.V. All rights reserved.
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Inhibited cardiac hypertrophy in proadrenomedullin NH2-Terminal 20 peptide-transgenic rat with unilateral ... Reviewed
Yuan-NingCao、北村和雄、桑迫健二、加藤丈司、西平賢作、浅田祐士郎、江藤胤尚
Journal of Adaptation Medicine 9 ( 1 ) 30 - 30 2005
Publishing type：Research paper (scientific journal)
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アドレノメデュリンの臨床応用 Reviewed
北村和雄
最新医学 60 ( 7 ) 1600 - 1605 2005
Publishing type：Research paper (scientific journal)
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内分泌学的検査 アドレノメデュリン Reviewed
北村和雄、江藤胤尚
日本臨牀 63 ( 8 ) 592 - 594 2005
Publishing type：Research paper (scientific journal)
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アドレノメデュリン研究の新展開（座談会） Reviewed
北村和雄、下澤達雄、伊藤裕、永谷憲歳
分子心血管病 6 ( 5 ) 447 - 458 2005
Publishing type：Research paper (scientific journal)
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総論：アドレノメデュリンと関連ペプチドの構造と作用 Reviewed
北村和雄
分子心血管病 6 ( 5 ) 459 - 463 2005
Publishing type：Research paper (scientific journal)
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新たな循環調節因子の研究を推進することで医学と医療の発展に貢献する-宮崎大学医学部内科学第一講座高血圧研究室 Reviewed
北村和雄
分子心血管病 6 ( 1 ) 105 - 108 2005
Publishing type：Research paper (scientific journal)
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アドレノメデュリンの最近の知見 Reviewed
北村和雄
日本妊娠高血圧学会雑誌 13 9 - 13 2005
Publishing type：Research paper (scientific journal)
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アドレノメデュリンの最近の知見 Recent advancement in adrenomedullin science Reviewed
北村和雄
日本妊娠高血圧学会プログラム・抄集 26 17 - 17 2005
Publishing type：Research paper (scientific journal)
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アドレノメデュリン(AM)とアドレノメデュリン2(AM2)のラットにおける組織中および血中濃度の比較 Reviewed
北村和雄、渡嘉敷真理子、Yuan-NingCao、加藤丈司、江藤胤尚
適応医学 9 ( 1 ) 30 - 30 2005
Publishing type：Research paper (scientific journal)