Papers - KITAMURA Kazuo
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Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2. 「"jointly worked"」 Reviewed
Kuwasako K, Kitamura K, Nagata S, Hikosaka T, Kato J
Biochemical and Biophysical Research Communications 392 380 - 385 2010.1
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1016
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アドレノメデュリン受容体の機能と役割 Reviewed
桑迫健二、加藤丈司、北村和雄
医学のあゆみ 233 ( 9 ) 851 - 856 2010
Publishing type：Research paper (scientific journal)
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アドレノメデュリン Reviewed
北村和雄
日本臨牀 68 ( 7 ) 630 - 632 2010
Publishing type：Research paper (scientific journal)
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ARB/利尿薬合剤の降圧効果と安全性 Reviewed
北俊弘、北村和雄
血圧 17 ( 12 ) 1028 - 1032 2010
Publishing type：Research paper (scientific journal)
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大腸MALT lymphoma術後11年目にdiffuse large B cell lymphomaを認めた一例 Reviewed
中島孝治、彦坂ともみ、星子新理、松本英丈、芦塚伸也、早稲田文子、押川勝太郎、稲津東彦、北村和雄、岩切太幹志、丸塚浩助
日本消化器病学会雑誌 107 ( suppl-2.2 ) 827 - 827 2010
Publishing type：Research paper (scientific journal)
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メタボリック症候群とペントラキシン3 Reviewed
小川恒夫、今村卓郎、北村和雄
生物試料分析 33 ( 4 ) 339 - 346 2010
Publishing type：Research paper (scientific journal)
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Uchiyama S., Goto S., Matsumoto M., Nagai R., Origasa H., Yamazaki T., Shigematsu H., Shimada K., Yamada N., Bhatt D.L., Steg P.G., Ikeda Y.
Journal of the Neurological Sciences 287 ( 1-2 ) 45 - 51 2009.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of the Neurological Sciences
The REduction of Atherothrombosis for Continued Health (REACH) Registry is a large, international, prospective cohort of patients with atherothrombosis or multiple (≥ 3) risk factors (MRFs) for atherothrombosis. Japanese patients (n = 5193) were enrolled into the REACH registry between August and December 2004. One-year event rate in patients with cerebrovascular disease (CVD) was compared with that of patients with symptomatic atherothrombosis at other locations. After one year (n = 5021), patients with CVD (n = 1962) experienced a higher rate of non-fatal strokes than patients with coronary artery disease (CAD), peripheral artery disease (PAD) or MRFs alone (2.77% vs. 1.28%, 2.07% and 1.56%, respectively), but a lower rate of non-fatal myocardial infarction (0.45% vs. 1.31%, 0.77% and 0.66%, respectively). Patients with CVD plus disease in ≥ 1 other vascular bed had higher rates of cardiovascular events than patients with CVD alone. Overall, event rates including non-fatal stroke, non-fatal myocardial infarction and cardiovascular death were higher for patients with CVD and PAD than for patients with CVD and CAD. Asymptomatic carotid stenosis ≥ 70% and ankle-brachial index < 0.9 were significant predisposing factors for stroke. Patients with CVD and co-existing atherothrombotic diseases had a high risk of recurrent events, including events arising in other vascular beds than originally diagnosed. © 2009 Elsevier B.V.
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Adrenomedullin treatment reduces intestinal inflammation and maintains epithelial barrier function in mice administered dextran sulphate sodium. "jointly worked" Reviewed
Ashizuka S, Inagaki-Ohara K, Kuwasako K, Kato J, Inatsu H, Kitamura K
Microbiol Immunol 53 ( 10 ) 573 - 581 2009.10
Language：English Publishing type：Research paper (scientific journal)
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Yamashita A., Matsuda S., Matsumoto T., Moriguchi-Goto S., Takahashi M., Sugita C., Sumi T., Imamura T., Shima M., Kitamura K., Asada Y.
Atherosclerosis 206 ( 2 ) 418 - 426 2009.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Atherosclerosis
Arterial thrombosis occurs in atherosclerotic, but rarely in non-atherosclerotic arteries. The present study investigates how hyperlipidemic condition affects thrombus formation on macrophage-rich neointima or normal intima in rabbits. Rabbits were fed with a 0.5% cholesterol diet, and then the femoral artery on one side of each rabbit was injured with a balloon catheter. Three weeks later, bilateral femoral arteries were similarly injured with a balloon catheter to produce thrombi on neointima and normal intima. We compared the expression and activity of intimal tissue factor (TF) as well as thrombus size and composition between these femoral arteries. 0.5% cholesterol diet combined with a balloon injury induced macrophage-rich neointima in injured arteries. The whole blood coagulation activity or plasma thrombin generation activity did not differ after consuming the 0.5% cholesterol diet for 4 weeks, and an anti-TF antibody did not affect the measured parameters. TF activities were increased in the neointima/media compared with normal intima/media. Balloon injury induced large platelet-fibrin thrombi on macrophage-rich neointima, whereas small platelet thrombi were produced in normal arteries even under hyperlipidemic conditions. Recombinant human tissue factor pathway inhibitor (25 μg/(kg min)) and argatroban (100 μg/(kg min)), a specific thrombin inhibitor, significantly reduced thrombus formation on induced neointima, but not on normal intima. Thrombin generation mediated by TF in intima contributes to thrombus formation on macrophage-rich neointima, but not on normal intima. The TF content in disrupted atherosclerotic plaques might play a more important role than hyperlipidemia in the development of atherothrombosis. © 2009 Elsevier Ireland Ltd. All rights reserved.
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Increased plasma levels of the mature and intermediate forms of adrenomedullin in obesity. "jointly worked" Reviewed
Nomura I, Kato J, Tokashiki M, Kitamura K
Regulatory Peptides 158 ( (1-3) ) 127 - 131 2009.8
Language：English Publishing type：Research paper (scientific journal)
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Pharmacological stimulation of soluble guanylate cyclase modulates hypoxia-inducible factor-1α in rat heart. "jointly worked" Reviewed
Tsuruda T, Hatakeyama K, Masuyama H, Sekita Y, Imamura T, Asada Y, Kitamura K
Tsuruda T, Hatakeyama K, Masuyama H, Sekita Y, Imamura T, Asada Y, Kitamura K 297 ( 4 ) 1274 - 1280 2009.8
Language：English Publishing type：Research paper (scientific journal)
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Flow cytometric analysis of the calcitonin receptor-like receptor domains responsible for cell-surface translocation of receptor activity-modifying proteins. "jointly worked" Reviewed
Kuwasako K, Kitamura K, Nagata S, Kato J
Biochemical and Biophysical Research Communications 384 ( 2 ) 249 - 254 2009.6
Language：English Publishing type：Research paper (scientific journal)
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Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart. "jointly worked" Reviewed
Masuyama H, Tsuruda T, Sekita Y, Hatakeyama K, Imamura T, Kato J, Asada Y, Stasch JP, Kitamura K
Hypertension Research 32 ( 7 ) 597 - 603 2009.5
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1038/hr.2009.64
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Association between body mass index and chronic kidney disease: a population-based, cross-sectional study of a Japanese community. "jointly worked" Reviewed
Nomura I, Kato J, Kitamura K
Nomura I, Kato J, Kitamura K 5 ( 1 ) 315 - 320 2009.4
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.2147/vhrm.s5522
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Interleukin-10 correlates with oxidized low density lipoprotein in coronary culprit plaques. "jointly worked" Reviewed
Nishihira K, Imamura T, Ishikawa T, Yamashita A, Shibata Y, Itabe H, Kitamura K, Asada Y
Thrombosis research 124 ( 3 ) 335 - 337 2009.3
Language：English Publishing type：Research paper (scientific journal)
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Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy. "jointly worked" Reviewed
Ferrario CM, Varagic J, Habibi J, Nagata S, Kato J, Chappell MC, Trask AJ, Kitamura K, Whaley-Connell A, Sowers JR
Am J Physiol Heart Circ Physiol 296 ( 4 ) 1184 - 1192 2009.2
Language：English Publishing type：Research paper (scientific journal)
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Effects of uroguanylin on natriuresis in experimental nephrotic rats. "jointly worked" Reviewed
Baba A, Fujimoto S, Kikuchi M, Kita T, Kitamura K
Nephrology 14 ( 1 ) 80 - 85 2009.2
Language：English Publishing type：Research paper (scientific journal)
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Recent therapeutic strategies improve renal outcome in patients with IgA nephropathy. "jointly worked" Reviewed
Komatsu H, Fujimoto S, Hara S, Fukuda A, Fukudome K, Yamada K, Sato Y, Kitamura K
American Journal of Nephrology 30 ( 1 ) 19 - 25 2009.1
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1159/000197116
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Effect of adrenomedullin on the cerebral circulation: relevance to primary headache disorders. "jointly worked" Reviewed
Petersen KA, Birk S, Kitamura K, Olesen J
Petersen KA, Birk S, Kitamura K, Olesen J 29 ( 1 ) 23 - 30 2009.1
Language：English Publishing type：Research paper (scientific journal)
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Minimal change nephrotic syndrome complicated with recurrence of malignant thymoma: an interesting case with remission due to steroid therapy of both nephrotic syndrome and thymoma] Reviewed
Akihiro Fukuda 1, Yuji Sato, Shuji Iwatsubo, Hiroyuki Komatsu, Ryousuke Nishiura, Keiichi Fukudome, Kazuhiro Yamada, Seiichiro Hara, Shouichi Fujimoto, Kazuo Kitamura
Nihon Jinzo Gakkai Shi 51 ( 2 ) 130 - 137 2009
Publishing type：Research paper (scientific journal)