Papers - KITAMURA Kazuo
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新しいアンジオテンシン関連ペプチドであるビッグアンジオテンシン-25の測定系の確立 Reviewed
永田さやか、福田顕弘、佐藤祐二、藤元昭一、井田隆徳、桑迫健二、渡嘉敷真理子、北村和雄
日本内分泌学会雑誌 91 ( 2 ) 643 - 643 2015
Publishing type：Research paper (scientific journal)
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新規アンジオテンシンペプチドの同定と機能解析 : ビッグアンジオテンシン-25 Reviewed
永田さやか、北村和雄
Angiotensin Research 12 ( 2 ) 88 - 94 2015
Publishing type：Research paper (scientific journal)
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新たなアンジオテンシン関連ペプチド : ビッグアンジオテンシン-25 Reviewed
永田さやか、北村和雄
日本内分泌学会雑誌 91 ( 1 ) 260 - 260 2015
Publishing type：Research paper (scientific journal)
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抗TNFα療法施行中にIGRA陽転化を認めたクローン病3症例 Reviewed
稲津東彦、芦塚伸也、久保衣里奈、黒石頌子、大野妙子、増田稔、三木吾郎、彦坂ともみ 松元英丈、中島孝治、北村和雄
日本消化器病学会雑誌 112 ( suppl-2 ) 928 - 928 2015
Publishing type：Research paper (scientific journal)
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IgA腎症を原疾患とする長期維持透析患者の特徴 Reviewed
小松弘幸、中川秀人、岩切太幹志、戸井田達典、福田顕弘、菊池正雄、佐藤祐二、北村和雄、藤元昭一
日本腎臓学会誌 56 56 ( 8 ) 1251 - 1259 2014.11
Language：Japanese Publishing type：Research paper (scientific journal)
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腎機能障害患者に対するビルダグリプチン使用経験～有効性と安全性の検討～ Reviewed
山下靖宏、福留慶一、上園繁弘、麻生和義、菊池正雄、佐藤祐二、北村和雄、藤元昭一
宮崎県医師会医学会誌 38 38 73 - 77 2014.9
Language：Japanese Publishing type：Research paper (scientific journal)
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Sakamoto S., Tsuruda T., Hatakeyama K., Imamura T., Asada Y., Kitamura K.
PLoS ONE 9 ( 8 ) e105739 2014.8
Language：English Publishing type：Research paper (scientific journal) Publisher：PLoS ONE
Background: The adventitia is suggested to contribute to vascular remodeling; however, the site-selective inflammatory responses in association with the development of atherosclerosis remain to be elucidated. Methods and Results: Wild-type or apolipoprotein E knockout male C57BL/6J background mice were fed standard chow for 16, 32, and 52 weeks, and the morphology of the aortic arch, descending aorta, and abdominal aorta was compared. Atheromatous plaque formation progressed with age, particularly in the aortic arch and abdominal aorta but not in the descending aorta. In addition, we found that the numbers of macrophages, T-lymphocytes, and microvessels, assessed by anti-F4/80, CD3, and CD31 antibodies, were higher in the adventitia of the abdominal aorta at 52 weeks. These numbers were positively correlated with plaque formation, but negatively correlated with elastin content, resulting in the enlargement of the total vessel area. In aortic tissues, interleukin-6 levels increased in the atheromatous plaque with age, whereas the level of regulated on activation, normal T cell expressed and secreted (RANTES) increased with age, and compared with other sites, it was particularly distributed in inflammatory cells in the adventitia of the abdominal aorta. Conclusion: This study suggests that adventitial inflammation contributes to the age-dependent structural alterations, and that the activation/inactivation of cytokines/chemokines is involved in the process. © 2014 Sakamoto et al.
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Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients Reviewed
R Kihara , Y Nagata , H Kiyoi , T Kato , E Yamamoto , K Suzuki , F Chen 1, N Asou 3, S Ohtake 4, S Miyawaki , Y Miyazaki , T Sakura , Y Ozawa , N Usui , H Kanamori , T Kiguchi , K Imai , N Uike , F Kimura , K Kitamura, C Nakaseko , M Onizuka , A Takeshita , F Ishida , H Suzushima , Y Kato , H Miwa , Y Shiraishi , K Chiba , H Tanaka , S Miyano, S Ogawa, T Naoe
Leukemia 28 ( 8 ) 1586 - 1595 2014.8
Publishing type：Research paper (scientific journal)
DOI： 10.1038/leu.2014.55
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Biological properties of adrenomedullin conjugated with polyethylene glycol Reviewed
Kubo K., Tokashiki M., Kuwasako K., Tamura M., Tsuda S., Kubo S., Yoshizawa-Kumagaye K., Kato J., Kitamura K.
Peptides 57 118 - 121 2014.7
Language：English Publishing type：Research paper (scientific journal) Publisher：Peptides
Adrenomedullin (AM) is a vasodilator peptide with pleiotropic effects, including cardiovascular protection and anti-inflammation. Because of these beneficial effects, AM appears to be a promising therapeutic tool for human diseases, while intravenous injection of AM stimulates sympathetic nerve activity due to short-acting potent vasodilation, resulting in increased heart rate and renin secretion. To lessen these acute reactions, we conjugated the N-terminal of human AM peptide with polyethylene glycol (PEG), and examined the biological properties of PEGylated AM in the present study. PEGylated AM stimulated cAMP production, an intracellular second messenger of AM, in cultured human embryonic kidney cells expressing a specific AM receptor in a dose-dependent manner, as did native human AM. The pEC50 value of PEGylated AM was lower than human AM, but no difference was noted in maximum response (Emax) between the PEGylated and native peptides. Intravenous bolus injection of 10 nmol/kg PEGylated AM lowered blood pressure in anesthetized rats, but the acute reduction became significantly smaller by PEGylation as compared with native AM. Plasma half-life of PEGylated AM was significantly longer than native AM both in the first and second phases in rats. In summary, N-terminal PEGylated AM stimulated cAMP production in vitro, showing lessened acute hypotensive action and a prolonged plasma half-life in comparison with native AM peptide in vivo. © 2014 Elsevier Inc.
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Osteoprotegerin is secreted into the coronary circulation: a possible association with the renin-angiotensin system and cardiac hypertrophy. Reviewed
Koyama S, Tsuruda T, Ideguchi T, Kawagoe J, Onitsuka H, Ishikawa T, Date H, Hatakeyama K, Asada Y, Kato J, Kitamura K
Horm Metab Res 46 2014.7
Language：English Publishing type：Research paper (scientific journal)
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Toida T., Sato Y., Shibata N., Kitamura K., Fujimoto S.
Blood Purification 38 ( 3-4 ) 174 - 179 2014.5
Language：English Publishing type：Research paper (scientific journal) Publisher：Blood Purification
Background/Aims: We investigated the method of switching EPO to CERA that does not cause a decrease in the Hb level. Methods: Fifty EPO-treated patients were randomly divided into two groups in which CERA was administered every two weeks (Q2W) or every four weeks (Q4W). After 8 weeks of treatment, the frequency of administration was changed to Q4W in the former. Follow-up was performed for 24 weeks. Results: There was no difference in the Hb level between the two groups until 6 weeks. In the Q2W group, the Hb maintained a stable level throughout a study period. However, in the Q4W group, the Hb level was significantly lower than in the Q2W group at weeks 9, 11, and 13. Conclusion: EPO switching to CERA without a decrease in the Hb level could be achieved by administering CERA every two weeks, but not every four weeks, for a specific period after switching.
DOI： 10.1159/000368391
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レニン・アンジオテンシン系の新展開：ヒト尿中の主要なアンジオテンシン関連ペプチド「ビッグアンジオテンシン-25」の発見． Reviewed
永田さやか、北村和雄
血管 37 37 73 - 79 2014.5
Language：Japanese Publishing type：Research paper (scientific journal)
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NT-proBNPの血液透析患者における予後予測 全死亡・脳心血管死・感染症死・腫瘍死における有用性 Reviewed
佐藤祐二、戸井田達典、中川秀人、菊池正雄、福田顕弘、山下靖宏、北村和雄、藤元昭一
日本透析医学会雑誌 47 2014.5
Language：Japanese Publishing type：Research paper (scientific journal)
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外来高血圧患者における尿中アルブミン 54クリニック、1207例における解析 Reviewed
山下靖宏、海老原史高、戸井田達典、岩切太幹志、福田顕弘、中川秀人、菊池正雄、佐藤祐二、北村和雄、藤元昭一
日本腎臓学会誌 56 2014.5
Language：Japanese Publishing type：Research paper (scientific journal)
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抗GBM腎炎における尿中podocyte mRNAの有用性の検討 Reviewed
福田顕弘、佐藤 祐二, 岩切 太幹志, 菊池 正雄, 北村 和雄, 藤元 昭一
日本腎臓学会誌 56 2014.5
Language：Japanese Publishing type：Research paper (scientific journal)
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レニン・アンジオテンシン・アルドステロン系研究の新展開、プロアンジオテンシン-12研究の最前線 Reviewed
加藤丈司、桑迫健二、小松洋一、永田さやか、北村和雄
Angiology Frontier 13 13 ( 1 ) 13 - 18 2014.4
Language：Japanese Publishing type：Research paper (scientific journal)
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Adrenomedullin does not contribute toward the development of abdominal aortic aneurysm in mice. Reviewed
Sakamoto S, Tsuruda T, Hatakeyama K, Shimosawa T, Asada Y, Kitamura K
Health 6 2014.4
Language：English Publishing type：Research paper (scientific journal)
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Association Between Renal Vasculature Changes and Generalized Atherosclerosis: An Autopsy Survey Reviewed
Iwakiri Takashi, Sato Yuichiro, Matsuura Yunosuke, Hatakeyama Kinta, Marutsuka Kousuke, Yamashita Atsushi, Fujimoto Shouichi, Kitamura Kazuo, Asada Yujiro
Journal of Atherosclerosis and Thrombosis 21 ( 2 ) 99 - 107 2014
Language：English Publishing type：Research paper (scientific journal) Publisher：Japan Atherosclerosis Society
<b><i>Aim</i></b>: To examine the association between renal vasculature changes and generalized atherosclerosis using autopsy cases.<br>
<b><i>Methods</i></b>: We histologically examined 107 autopsy patients(mean age, 68.4 years; 64% men; 81% non-CVD) to investigate the association between renal vasculature changes and generalized atherosclerosis. We measured the intima/media(I/M) ratio for the renal, intrarenal and systemic arteries(coronary, cerebral, common carotid and common iliac), calculated the rates of arteriolar hyalinization and global glomerulosclerosis and evaluated the frequency of advanced lesions(AHA classification ≥IV) in the systemic arteries.<br>
<b><i>Results</i></b>: The I/M ratios of the renal and intrarenal arteries and the rate of global glomerulosclerosis increased with age, while the rates of arteriolar hyalinization and global glomerulosclerosis were associated with diabetes and hypertension(all <i>p</i>＜0.05). The I/M ratio of the coronary artery was independently associated with the rate of global glomerulosclerosis(<i>p</i>＜0.05). The frequency of advanced atherosclerotic lesions in the coronary and cerebral arteries was also correlated with the I/M ratio of the renal artery and rates of arteriolar hyalinization and global glomerulosclerosis(all <i>p</i>＜0.05). The frequency of advanced lesions in the cerebral and common carotid arteries was independently associated with the I/M ratio of the renal artery and the rate of renal arteriolar hyalinization(odds ratio(OR) with [95% confidence interval]; 5.09 [1.15-27.9] and 4.11 [1.38-13.9], respectively).<br>
<b><i>Conclusions</i></b>: The results of this study demonstrated that pathological changes in four portions of the renal vasculature differ. Renal vasculature changes except the intrarenal arteries were significantly associated with those observed in the cerebral, common carotid and coronary arteries.DOI： 10.5551/jat.19869
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Kawagoe Junji, Ishikawa Tetsunori, Iwakiri Hironao, Date Haruhiko, Imamura Takuroh, Kitamura Kazuo
International Heart Journal 55 ( 3 ) 239 - 243 2014
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：International Heart Journal Association
Adiponectin has antiatherosclerotic properties and is also produced in the local coronary circulation. We previously reported that significantly less adiponectin was produced in the coronary circulation of patients with than without coronary artery disease (CAD). The goal of this study was to determine whether adiponectin production in the coronary circulation could predict future cardiovascular events in patients with CAD.<br>Forty-eight CAD patients whose left anterior descending coronary arteries required percutaneous coronary intervention (PCI) were enrolled. The amount of adiponectin production in the coronary circulation was defi ned as the plasma adiponectin level at the great cardiac vein minus that at the orifice of the left coronary artery. All patients were divided by adiponectin production level in the coronary circulation into the adiponectin-positive production group (> 0 <i>µ</i>g/ mL) and adiponectin-negative production group (≤ 0 <i>µ</i>g/mL). Median follow-up period was 66 months (maximum, 108 months). The primary endpoint was the combined occurrence of major adverse cardiovascular events (MACE), including rehospitalization due to unstable angina, heart failure, nonfatal myocardial infarction, revascularization with PCI or coronary artery bypass grafting, ischemic stroke, and cardiovascular death.<br>Sixteen MACE occurred. The incidence of MACE was signifi cantly higher in the adiponectin-negative production group than in the adiponectin-positive production group (<i>P</i> = 0.02). In multivariate analysis, adiponectin-negative production was a predictor of MACE (<i>P</i> = 0.03). Kaplan-Meier analysis revealed that the MACE-free rate was signifi cantly lower in the adiponectin-negative production group than in the adiponectin-positive production group.<br>Adiponectin production in the coronary circulation with CAD may be associated with MACE.
DOI： 10.1536/ihj.13-287
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Inhibited cardiac hypertrophy in proadrenomedullin NH2-Terminal 20 peptide-transgenic rat with unilateral ... Reviewed
Yuan-NingCao、北村和雄、桑迫健二、加藤丈司、西平賢作、浅田祐士郎、江藤胤尚
Journal of Adaptation Medicine 9 ( 1 ) 30 - 30 2014
Publishing type：Research paper (scientific journal)