Papers - KITAMURA Kazuo
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当科にて経験した好酸球性消化管病変を有する5例の検討 Reviewed
原口大、稲津東彦、中島孝治、芦塚伸也、松本英丈、星子新理、三木吾郎、三宮一朗、彦坂ともみ、片山陽平、北村和雄
日本消化器病学会雑誌 109 ( suppl-2 ) 862 - 862 2012
Publishing type：Research paper (scientific journal)
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CRT-D植込みを契機に頻回作動を呈し, ステロイド投与にて改善した心サルコイドーシスの1例 Reviewed
川越純志、和田美沙、西山美保、井手口武史、鬼塚久充、鶴田敏博、石川哲憲、今村卓郎、北村和雄
Journal of Arrhythmia 28 ( suppl ) 342 - 342 2012
Publishing type：Research paper (scientific journal)
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維持透析患者における炭酸ランタン(LC)内服継続と炭酸カルシウム(CaC)単剤内服継続の比較検討 Reviewed
戸井田達典、福留慶一、千代反田晋、佐藤祐二、北村和雄、藤元昭一
Therapeutic Research 33 ( 66 ) 929 - 933 2012
Publishing type：Research paper (scientific journal)
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当科にて経験した膵・消化管神経内分泌癌5例の検討 Reviewed
原口大、稲津東彦、中島孝治、芦塚伸也、松本英丈、星子新理、三木吾郎、三宮一朗、彦坂ともみ、片山陽平、北村和雄
日本消化器病学会雑誌 109 ( suppl-2 ) 872 - 872 2012
Publishing type：Research paper (scientific journal)
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G蛋白共役型受容体キナーゼ (GRK) によるアドレノメデュリン (AM) Reviewed
桑迫健二、北村和雄、永田さやか、加藤丈司
日本内分泌学会雑誌 88 ( 1 ) 372 - 372 2012
Publishing type：Research paper (scientific journal)
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1型アドレノメデュリン受容体複合体のユニークな分子機構と循環制御 Reviewed
桑迫健二、北村和雄、永田さやか、加藤丈司
日本薬理学雑誌 140 ( 1 ) 8 - 13 2012
Publishing type：Research paper (scientific journal)
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1型アドレノメデュリン受容体の細胞内ヘリックス8の役割 Reviewed
桑迫健二、北村和雄、永田さやか、彦坂ともみ、野崎尚美、加藤丈司
日本薬理学会部会（日本薬理学雑誌） 139 ( 3 ) 36 - 36 2012
Publishing type：Research paper (scientific journal)
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ネフローゼ症候群における脂質の検討 Reviewed
菊池正雄、藤元昭一、岩坪修
Therapeutic Research 33 ( 2 ) 183 - 185 2012
Publishing type：Research paper (scientific journal)
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ARBとカルシウム拮抗薬または利尿薬の併用降圧療法の比較：肥満の有無による降圧効果とアルドステロン濃度変化の差異 Reviewed
加藤丈司、桑迫健二、北俊弘、北村和雄
日本内分泌学会雑誌 88 ( 2 ) 829 - 829 2012
Publishing type：Research paper (scientific journal)
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Presence of older thrombus in patients with late and very late drug-eluting stent thrombosis.「"jointly worked"」 Reviewed
Nishihira K, Hatakeyama K, Kuriyama N, Nomura K, Fukushima Y, Inoue Y, Nakama T, Mine D, Sagara S, Ashikaga K, Matsuyama A, Kitamura K, Shibata Y, Asada Y
Cardiol 59 ( 1 ) 57 - 63 2011.10
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1016
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Adrenomedullin production is increased in colorectal adenocarcinomas; its relation to matrix metalloproteinase-9.「"jointly worked"」 Reviewed
Hikosaka T, Tsuruda T, Nagata S, Kuwasako K, Tsuchiya K, Hoshiko S, Inatsu H, Chijiiwa K, Kitamura K
Peptides 32 ( 9 ) 1825 - 1831 2011.8
Language：English Publishing type：Research paper (scientific journal)
DOI： "
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一般住民における血中アルドステロン値の規定因子および血中アルドステロン値とインスリン感受性との関連．（共著） Reviewed
野村郁夫，加藤丈司，北村和雄
血圧 18 ( 8 ) 771 - 773 2011.8
Language：Japanese Publishing type：Research paper (scientific journal)
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Hashimoto K., Tsujita M., Miyazaki T., Kitamura K., Yamazaki M., Shin H.S., Watanabe M., Sakimura K., Kano M.
Proceedings of the National Academy of Sciences of the United States of America 108 ( 24 ) 9987 - 9992 2011.6
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Proceedings of the National Academy of Sciences of the United States of America
Neural circuits are initially redundant but rearranged through activity-dependent synapse elimination during postnatal development. This process is crucial for shaping mature neural circuits and for proper brain function. At birth, Purkinje cells (PCs) in the cere-bellum are innervated by multiple climbing fibers (CFs) with similar synaptic strengths. During postnatal development, a single CF is selectively strengthened in each PC through synaptic competition, the strengthened single CF undergoes translocation to a PC dendrite, and massive elimination of redundant CF synapses follows. To investigate the cellular mechanisms of this activity-dependent synaptic refinement, we generated mice with PC-selective deletion of the Ca v2.1 P/Q-type Ca2+ channel, the major voltage-dependent Ca2+ channel in PCs. In the PC-selective Cav2.1 knockout mice, Ca2+ transients induced by spontaneous CF inputs are markedly reduced in PCs in vivo. Not a single but multiple CFs were equally strengthened in each PC from postnatal day 5 (P5) to P8, multiple CFs underwent translocation to PC dendrites, and subsequent synapse elimination until around P12 was severely impaired. Thus, P/ Q-type Ca2+ channels in postsynaptic PCs mediate synaptic competition among multiple CFs and trigger synapse elimination in developing cerebellum.
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Shared and separate functions of the RAMP-based adrenomedullin receptors. 「"jointly worked"」 Reviewed
Kuwasako K, Kitamura K, Nagata S, Hikosaka T, Takei Y, Kato J
Peptides 32 ( 7 ) 1540 - 1550 2011.5
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.1016
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Clinical features and outcomes of eosinophilic myocarditis patients treated with prednisolone at a single institution over a 27-year period.「"jointly worked"」 Reviewed
Kawano S, Kato J, Kawano N, Yoshimura Y, Masuyama H, Fukunaga T, Sato Y, Maruyama H, Mihara K, Ueda A, Toyoda K, Imamura T, Kitamura K
Internal Medicine 50 ( 9 ) 975 - 981 2011.5
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.2169
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Associations of plasma pentraxin 3 and monocyte chemoattractant protein-1 concentrations with cardiovascular disease in patients with chronic kidney disease. 「"jointly worked"」 Reviewed
Nishi K, Imamura T, Kitamura K, Ogawa T, Fujimoto S, Kakitsubata Y, Ishikawa T, Asada Y, Kodama T
Renal Failure 33 ( 4 ) 398 - 404 2011.2
Language：English Publishing type：Research paper (scientific journal)
DOI： 10.3109
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Komatsu Hiroyuki, Arimura Yasuji, Imamura Takuroh, Kitamura Kazuo, Okayama Akihiko, Hayashi Katsuhiro
Igaku Kyoiku / Medical Education (Japan) 42 ( 2 ) 55 - 63 2011
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Society for Medical Education
Cardiac patient simulators are commonly used in Japanese educational institutions; however, most institutions have not established concrete learning objectives or strategies for mastering physical examination of the circulatory system, including cardiac auscultation. In this study, we propose clear learning objectives and strategies for simulator practice for fifth-year medical students who have passed the objective structured clinical examination, and explored their educational effectiveness.<br>1)The subjects were fifth-year medical students (n=94) at the University of Miyazaki. Learning objectives were the mastery of the sequential physical examination and the ability to distinguish 6 cardiac findings, including normal status. The subjects were evaluated with a checklist before and after lectures and simulator practice.<br>2)The mean score (maximum score=14) significantly increased from before simulator practice (2.2±0.9) to after simulator practice (11.4±1.5; p<0.001). There was no difference in scores after practice among the cardiac diseases.<br>3)Before practice more than 50% of subjects could use a stethoscope on only right positions and could indicate only the maximum point of a cardiac murmur; in contrast, after practice more than 90% of the subjects could sequentially describe physical findings and accurately predict cardiac diseases.<br>4)In a questionnaire administered after practice, 83% of the subjects answered that all physicians should acquire proficiency in cardiac auscultation regardless of their specialty.<br>Simulator practice with clear learning objectives may help improve clinical examination skills when both time and human resources are limited. The reevaluation of the program's continuing educational effectiveness and the establishment of an iterative learning program will be needed.
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活動期潰瘍性大腸炎寛解導入療法としてのアドレノメデュリン持続静注療法の経験 Reviewed
稲津東彦、芦塚伸也、北村和雄
日本消化器病学会雑誌 108 ( suppl-2 ) 862 - 862 2011
Publishing type：Research paper (scientific journal)
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Komatsu Hiroyuki, Arimura Yasuji, Imamura Takuroh, Kitamura Kazuo, Okayama Akihiko, Hayashi Katsuhiro
Igaku Kyoiku / Medical Education (Japan) 42 ( 2 ) 55 - 63 2011
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Society for Medical Education
Cardiac patient simulators are commonly used in Japanese educational institutions; however, most institutions have not established concrete learning objectives or strategies for mastering physical examination of the circulatory system, including cardiac auscultation. In this study, we propose clear learning objectives and strategies for simulator practice for fifth-year medical students who have passed the objective structured clinical examination, and explored their educational effectiveness.<br>1)The subjects were fifth-year medical students (n=94) at the University of Miyazaki. Learning objectives were the mastery of the sequential physical examination and the ability to distinguish 6 cardiac findings, including normal status. The subjects were evaluated with a checklist before and after lectures and simulator practice.<br>2)The mean score (maximum score=14) significantly increased from before simulator practice (2.2±0.9) to after simulator practice (11.4±1.5; p<0.001). There was no difference in scores after practice among the cardiac diseases.<br>3)Before practice more than 50% of subjects could use a stethoscope on only right positions and could indicate only the maximum point of a cardiac murmur; in contrast, after practice more than 90% of the subjects could sequentially describe physical findings and accurately predict cardiac diseases.<br>4)In a questionnaire administered after practice, 83% of the subjects answered that all physicians should acquire proficiency in cardiac auscultation regardless of their specialty.<br>Simulator practice with clear learning objectives may help improve clinical examination skills when both time and human resources are limited. The reevaluation of the program's continuing educational effectiveness and the establishment of an iterative learning program will be needed.
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O07-4 一般住民における血中アルドステロン値の規定因子および血中アルドステロン値とインスリン感受性との関連 Reviewed
野村郁夫、加藤丈司、北村和雄
日本内分泌学会雑誌 87 ( 2 ) 779 - 779 2011
Publishing type：Research paper (scientific journal)