論文 - 北村 和雄
-
Nishikimi T., Morimoto A., Ishikawa K., Saito Y., Kangawa K., Matsuo H., Kitamura K., Takishita S., Matsuoka H.
Clinical and Experimental Hypertension 19 ( 4 ) 503 - 518 1997年5月
掲載種別：研究論文（学術雑誌） 出版者・発行元：Clinical and Experimental Hypertension
The purpose of this study was to investigate the effect of exercise on plasma concentrations of adrenomedullin, brain natriuretic peptide (BNP), and atrial natriuretic peptide (ANP) in patients with essential hypertension (n = 15) and in normotensive controls (n = 10). Exercise consisted of two fixed workloads, 40 and 80 watts of work load using a supine bicycle ergometer. Plasma levels of all three peptides at rest were significantly higher in hypertensives than in controls. Plasma concentrations of ANP increased with exercise in both groups and had greater increments in hypertensive patients than in normotensives. Plasma concentrations of BNP increased only in patients with hypertension and the levels of increase correlated with basal plasma BNP levels (r = 0.94, p < 0.001) and with left ventricular mass (r = 0.62, p < 0.01) determined by echocardiography. In contrast, plasma adrenomedullin did not change with exercise in either group. These results suggest that secretion patterns of these peptides are regulated by different mechanisms and that the amount and kind of peptides mobilized by exercise may depend on the underlying diseases or pathophysiologic condition.
-
Production of adrenomedullin in human vascular endothelial cells 査読あり
Ishihara T., Kato J., Kitamura K., Katoh F., Fujimoto S., Kangawa K., Tanenao E.
Life Sciences 60 ( 20 ) 1763 - 1769 1997年4月
掲載種別：研究論文（学術雑誌） 出版者・発行元：Life Sciences
To examine the production of adrenomedullin (AM) in human vascular endothelial cells, AM concentration in cultured endothelial cells derived from the human umbilical vein and the conditioned media of the cells were measured in the present study. The cultured endothelial cells secreted immunoreactive AM (ir-AM) into the medium at a rate of 14.7 ± 3.0 fmol/106 cells/24 h with an intracellular ir-AM of 5.2 ± 0.8 fmol/106 cells. Analysis by reverse phase high performance-liquid chromatography (HPLC) showed that ir-AM in both the cells and the conditioned medium eluted at the position identical to that of human AM(1-52). Treatment with dexamethasone significantly augmented the secretion of ir-AM from the cells without any effect on the intracellular ir-AM concentration. Northern blot analysis showed not only the presence of the 1.6 kb human AM precursor mRNA in the endothelial cells, but also its increased expression in the dexamethasone-treated cells. Thus, AM was synthesized and secreted by the human endothelial cells of the umbilical vein, and glucocorticoid augmented the AM production. These findings suggest not only the role of AM as a local modulator of the vascular tone but also the possibility that endothelial cells contribute to circulating AM in the human blood.
-
Nishikimi T., Nagata S., Sasaki T., Tomimoto S., Matsuoka H., Takishita S., Kitamura K., Miyata A., Matsuo H., Kangawa K.
Heart 78 ( 4 ) 390 - 395 1997年
掲載種別：研究論文（学術雑誌） 出版者・発行元：Heart
Objective - To examine the pathophysiological significance of adrenomedullin in the pulmonary circulation by investigating the relation between plasma concentrations of adrenomedullin and central haemodynamics in patients with mitral stenosis. Methods - Plasma concentrations of adrenomedullin in blood samples obtained from the femoral veins pulmonary artery, left atrium, and aorta were measured by a newly developed specific radio-immunoassay in 23 consecutive patients with mitral stenosis (16 females and seven males, aged 55 (10) years (mean (SD)) who were undergoing percutaneous mitral commissurotomy. Results - Patients with mitral stenosis had higher concentrations of adrenomedullin than age matched normal controls (3.9 (0.3) v 2.5 (0.3) pmol/l, p < 0.001). There was a reduction in adrenomedullin concentrations between the pulmonary artery and the left atrium (3.8 (0.2) v 3.2 (0.4) pmol/l, p < 0.001). The venous concentrations of adrenomedullin correlated with mean pulmonary artery pressure (r = 0.65, p < 0.001), total pulmonary vascular resistance (r = 0.83, p < 0.0001), and pulmonary vascular resistance (r = 0.65, p < 0.001). Plasma concentrations of adrenomedullin did not change immediately after percutaneous mitral commissurotomy; however, they decreased significantly one week later. Conclusions - Plasma concentrations of adrenomedullin are increased in patients with mitral stenosis. This may help to attenuate the increased pulmonary arterial resistance in secondary pulmonary hypertension due to mitral stenosis.
DOI： 10.1136/hrt.78.4.390
-
Cardiac secretion of adrenomedullin by percutaneous transluminal coronary angioplasty 査読あり
Etoh T., Doi H., Hanada Y., Kato J., Imamura T., Kitamura K., Koiwaya Y., Eto T.
Hormone and Metabolic Research 29 ( 10 ) 530 - 531 1997年
-
Plasma proadrenomedullin N-terminal 20 peptide (PAMP) in patients with congestive heart failure 査読あり
Etoh T., Kato J., Washimine H., Imamura T., Kitamura K., Koiwaya Y., Kangawa K., Eto T.
Hormone and Metabolic Research 29 ( 1 ) 46 - 47 1997年
掲載種別：研究論文（学術雑誌） 出版者・発行元：Hormone and Metabolic Research
-
Khan A.I., Kato J., Kitamura K., Kangawa K., Eto T.
Clinical and Experimental Pharmacology and Physiology 24 ( 2 ) 139 - 142 1997年
掲載種別：研究論文（学術雑誌） 出版者・発行元：Clinical and Experimental Pharmacology and Physiology
1. The hypotensive effect of chronically infused human adrenomedullin (hAM), a potent vasodilator peptide that has been reported to have a natriuretic action, was examined In normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). 2. Conscious WKY rats and SHR were infused with 200 ng/h synthetic hAM for 14 days by means of osmotic minipumps, Control groups were infused at the same schedule with 0.9% saline. Systolic blood pressure (SBP) and daily urinary excretion of Na+ and K+ were measured before and during the infusion period. In addition, plasma renin activity (PRA), aldosterone and hAM concentrations were measured on day 14 of infusion, 3. A significant reduction in SBP was observed in hAM treated SHR at day 2 and SBP remained significantly lower throughout the experiment compared with control SHR. Similarly, SBP in the hAM-treated WKY rats was found to be significantly lower than in control WKY rats during infusion, However, the hypotensive effect was not accompanied by any significant increase in urinary volume or Na+ excretion in hAM-treated rats of either strain. Chronic infusion with hAM significantly suppressed PRA and lowered the concentration of plasma aldosterone in WKY rats but not in SHR. The plasma hAM levels in treated WKY rats and SHR were 0.9 ± 0.4 and 0.6 ± 0.2 fmol/ml, respectively. 4. These findings demonstrate that chronically infused hAM has a hypotensive effect in both WKY rats and SHR without an increase in urinary volume or Na+ excretion at a plasma AM concentration within the physiological limit.
-
Effect of exercise on plasma adrenomedullin and natriuretic peptide levels in myocardial infarction 査読あり
Morimoto A., Nishikimi T., Takaki H., Okano Y., Matsuoka H., Takishita S., Kitamura K., Miyata A., Kangawa K., Matsuo H.
Clinical and Experimental Pharmacology and Physiology 24 ( 5 ) 315 - 320 1997年
掲載種別：研究論文（学術雑誌） 出版者・発行元：Clinical and Experimental Pharmacology and Physiology
1. We investigated the effect of exercise on plasma adrenomedullin, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) concentrations and studied the relationship between these peptides and haemodynamic parameters in nine patients with old myocardial infarction (MI) and in eight normal subjects. 2. The exercise protocol consisted of two fixed work loads (40 and 80 W) for 4 min each and venous blood samples were taken at rest, during each exercise stage and after exercise while monitoring the mean arterial pressure (MAP) and heart rate (HR). In MI, pulmonary arterial pressure (PAP), pulmonary capillary wedge pressure (PCWP), left ventricular end-diastolic pressure (LVEDP) and cardiac output (CO) were measured throughout exercise. 3. Adrenomedullin levels did not significantly increase with exercise. Adrenomedullin levels correlated with PAP and PCWP at rest (P < 0.05). Atrial natriuretic peptide levels correlated with PAP, PCWP and LVEDP throughout exercise (P < 0.05) but, on multiple regression analysis, PCWP correlated only with ANP (P<0.01). Brain natriuretic peptide levels correlated with LVEDP throughout exercise (P < 0.01) and its increment correlated closely with basal BNP levels at rest (P < 0.01). 4. These results suggest that adrenomedullin does not respond to the acute haemodynamic changes of exercise, whereas ANP responds to it and PCWP is the major stimulus factor. Brain natriuretic peptide responds to exercise in proportion to the basal synthesis of BNP in patients with left ventricular dysfunction and LVEDP may play a role in increasing BNP during exercise.
-
悪性褐色細胞腫多発性肝転移例に対する, 経肝動脈塞栓療法におけるアドレノメデユリンの動態 査読あり
芦澤直人、高橋和宏、馬場是明、鈴木伸、北村和雄、江藤胤尚、矢野捷介
日本内分泌学会雑誌 73 ( 5 ) 355 - 355 1997年
掲載種別：研究論文（学術雑誌）
-
アドレノメデュリン(AM)の多彩な作用 査読あり
北村和雄
医学のあゆみ 182 ( 2 ) 136 - 137 1997年
掲載種別：研究論文（学術雑誌）
-
Adrenomedullin動態と脳血管障害 査読あり
竹下啓、高本俊介、小松本悟、奈良昌治、北村和雄
脳卒中 19 ( 6 ) 548 - 548 1997年
掲載種別：研究論文（学術雑誌）
-
心血管系でのアドレノメデュリンとPAMP 査読あり
北村和雄、加藤丈司、鶴田敏博、寒川賢治、江藤胤尚
日本内分泌学会雑誌 73 ( 5 ) 330 - 330 1997年
掲載種別：研究論文（学術雑誌）
-
新しい循環調節ペプチド"アドレノメデュリン"と"PAMP"の発見とその基礎的・臨床的研究 査読あり
北村和雄
日本内分泌学会雑誌 73 ( 2 ) 63 - 63 1997年
担当区分：筆頭著者 掲載種別：研究論文（学術雑誌）
-
アドレノメデュリン 査読あり
北村和雄
心臓 29 ( 4 ) 281 - 289 1997年
担当区分：筆頭著者 掲載種別：研究論文（学術雑誌）
-
アドレノメデュリンとPAMP 査読あり
北村和雄、江藤胤尚
日本臨牀 55 ( 8 ) 1963 - 1970 1997年
担当区分：筆頭著者 掲載種別：研究論文（学術雑誌）
-
起立性低血圧を認める糖尿病性神経障害患者と健常者におけるティルティング負荷に対する血中アドレノメデュリン(AM)動態 査読あり
中村
日本内分泌学会雑誌 73 ( 2 ) 280 - 280 1997年
掲載種別：研究論文（学術雑誌）
-
覚醒ラットにおけるアドレノメデュンの末梢および中枢作用について 査読あり
斉田光彦、下川歩、國武孝人、加藤和男、白阪哲朗、北村和雄、江藤胤尚、河南洋
日本内分泌学会雑誌 73 ( 5 ) 355 - 355 1997年
掲載種別：研究論文（学術雑誌）
-
アドレノメデュリン 査読あり
杉田江里、谷山松雄、伴良雄、北村和雄
病理と臨床 15 ( 3 ) 253 - 258 1997年
掲載種別：研究論文（学術雑誌）
-
本態性高血圧症に対する塩酸ベニジピン(コニール(R))長期投与の検討-宮崎コニール研究会- 査読あり
江藤胤尚、木田修、北村和雄、児玉健二、近藤宏一、比嘉利信、熊谷治士、田口利文、市来能成、石山雄一郎
臨牀と研究 78 ( 8 ) 2079 - 2086 1997年
掲載種別：研究論文（学術雑誌）
-
長期持続静注アドレノメデュリン(AM)の降圧効果-無麻酔無拘束の高血圧自然発症ラット(SHR)およびWistar-Kyotoラット(WKY)を用いた検討- 査読あり
加藤丈司、カーンIアズハルル、北村和雄、寒川賢治、江藤胤尚
Therapeutic Research 18 ( 7 ) 2201 - 2204 1997年
掲載種別：研究論文（学術雑誌）
-
呼吸器疾患における血漿アドレノメデュリンおよびPAMP濃度に関する検討 査読あり
下窪徹、比嘉利信、田中雅之、石畠英昭、鬼塚黎子
臨牀と研究 74 ( 10 ) 2507 - 2510 1997年
掲載種別：研究論文（学術雑誌）