論文 - 北村 和雄
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虚血性心疾患診断における冠動脈領域別の位相解析指標の有用性の検討. 査読あり
寺田珠沙、長町茂樹、鬼塚久充、水谷陽一、平井俊範、北村和雄
臨床放射線 63 ( 2 ) 185 - 90 2018年
掲載種別：研究論文（学術雑誌）
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周術期バイオマーカーとしてのアドレノメデュリン 査読あり
丸田豊明、太田尾剛、与那覇哲、北村和雄、恒吉勇男
循環制御 39 ( 3 ) 169 - 171 2018年
掲載種別：研究論文（学術雑誌）
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学習・記憶障害に対する持続性アドレノメデュリン誘導体の効果 査読あり
永田さやか、山崎基生、北村和雄
日本内分泌学会雑誌 94 ( 1 ) 340 - 340 2018年
掲載種別：研究論文（学術雑誌）
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Good J.M., Mahoney M., Miyazaki T., Tanaka K.F., Sakimura K., Watanabe M., Kitamura K., Kano M.
Cell Reports 21 ( 8 ) 2066 - 2073 2017年11月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Cell Reports
Neural circuits undergo massive refinements during postnatal development. In the developing cerebellum, the climbing fiber (CF) to Purkinje cell (PC) network is drastically reshaped by eliminating early-formed redundant CF to PC synapses. To investigate the impact of CF network refinement on PC population activity during postnatal development, we monitored spontaneous CF responses in neighboring PCs and the activity of populations of nearby CF terminals using in vivo two-photon calcium imaging. Population activity is highly synchronized in newborn mice, and the degree of synchrony gradually declines during the first postnatal week in PCs and, to a lesser extent, in CF terminals. Knockout mice lacking P/Q-type voltage-gated calcium channel or glutamate receptor δ2, in which CF network refinement is severely impaired, exhibit an abnormally high level of synchrony in PC population activity. These results suggest that CF network refinement is a structural basis for developmental desynchronization and maturation of PC population activity. In the cerebellum, the climbing fiber to Purkinje cell network is extensively remodeled during postnatal development. Good et al. show that in vivo population activity of Purkinje cells in response to climbing fiber synaptic inputs is highly synchronized in newborn mice and massively desynchronized due to climbing fiber network refinement.
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Urinary podocyte and TGF-β1 mRNA as markers for disease activity and progression in anti-glomerular basement membrane nephritis 査読あり
Fukuda A, Minakawa A, Sato Y, Iwakiri T, Iwatsubo S, Komatsu H, Kikuchi M, Kitamura K, Wiggins RC, Fujimoto S
Nephrology Dialysis Transplantation 32 ( 11 ) 1818 - 1830 2017年11月
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Transient Left Ventricular Contractile Dysfunction during the Treatment of Rhabdomyolysis: A Case Report and Literature Review 査読あり
Tsuruda T, Shinohara N, Ogata M, Kitamura K, Ochiai H
Internal Medicine 2017年10月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Plasma levels of natriuretic peptides and year-by-year blood pressure variability: a population-based study 査読あり
Kato J, Kawagoe Y, Jiang D, Kuwasako K, Shimamoto S, Igarashi K, Tokashiki M, Kitamura K
J Hum Hypertens 31 ( 8 ) 525 - 529 2017年8月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Kuwasako K., Kitamura K., Nagata S., Sekiguchi T., Jiang D., Murakami M., Hattori Y., Kato J.
Biochemical and Biophysical Research Communications 490 ( 3 ) 2017年8月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Biochemical and Biophysical Research Communications
The authors regret that the first and last names of the fifth author were retrograde. The authors would like to apologise for any inconvenience caused.
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副腎静脈還流異常により診断に苦慮したアルドステロン産生腺腫の1例 査読あり
新森 徳長, 北 俊弘, 川口 隆久, 宮下 和季, 栗原 勲, 伊藤 裕, 小黒 草太, 中塚 誠之, 古小路 英二, 北村 和雄
日本内科学会雑誌 106 ( 8 ) 1632 - 1639 2017年8月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：一般社団法人 日本内科学会
56歳，男性．高血圧と低カリウム血症を呈し，内分泌負荷試験で原発性アルドステロン症（primary aldosteronism：PA）が強く疑われた．CT（computed tomography）で左副腎に8 mm大の腺腫を認めるも，通常の副腎静脈サンプリング（adrenal venous sampling：AVS）ではアルドステロン過剰分泌は認めなかった．CTを併用した副腎動脈造影で，左副腎腺腫から左腎被膜静脈と左腎静脈分枝への導出を同定し，アルドステロン過剰分泌を証明した．腹腔鏡下左副腎摘除術にて治癒した．副腎静脈還流異常により通常のAVSでは診断不能な症例が存在する．
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Inhibitory effects of losartan and azelnidipine on augmentation of blood pressure variability induced by angiotensin II in rats. 査読あり
Jiang D, Kawagoe Y, Kuwasako K, Kitamura K, Kato J
Eur J Pharmacol 806 91 - 95 2017年7月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Anti-Inflammatory Effects of PEGylated Human Adrenomedullin in a Mouse DSS-Induced Colitis Model. 査読あり
Nagata S, Yamasaki M, Kitamura K
Drug development research 78 ( 3-4 ) 129 - 134 2017年6月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1002/ddr.21383
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Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice 査読あり
Nakai N., Nagano M., Saitow F., Watanabe Y., Kawamura Y., Kawamoto A., Tamada K., Mizuma H., Onoe H., Watanabe Y., Monai H., Hirase H., Nakatani J., Inagaki H., Kawada T., Miyazaki T., Watanabe M., Sato Y., Okabe S., Kitamura K., Kano M., Hashimoto K., Suzuki H., Takumi T.
Science Advances 3 ( 6 ) e1603001 2017年6月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Science Advances
Serotonin is a critical modulator of cortical function, and its metabolism is defective in autism spectrum disorder (ASD) brain. How serotonin metabolism regulates cortical physiology and contributes to the pathological and behavioral symptoms of ASD remains unknown. We show that normal serotonin levels are essential for the maintenance of neocortical excitation/inhibition balance, correct sensory stimulus tuning, and social behavior. Conversely, low serotonin levels in 15q dup mice (a model for ASD with the human 15q11-13 duplication) result in impairment of the same phenotypes. Restoration of normal serotonin levels in 15q dup mice revealed the reversibility of a subset of ASD-related symptoms in the adult. These findings suggest that serotonin may have therapeutic potential for discrete ASD symptoms.
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β-arrestins negatively control human adrenomedullin type 1-receptor internalization. 査読あり
Kuwasako K, Kitamura K, Nagata S, Sekiguchi T, Danfeng J, Murakami M, Hattori Y, Kato J
Biochemical and biophysical research communications 487 ( 2 ) 438 - 443 2017年5月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Getting Osteoporotic Fracture Risk into Vascular Structure and Function: Do you know your FRAX® score? 招待あり 査読あり
Toshihiro Tsuruda, Kazuo Kitamura
Circulation Journal 81 ( 6 ) 786 - 787 2017年5月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Matsuura Y., Yamashita A., Zhao Y., Iwakiri T., Yamasaki K., Sugita C., Koshimoto C., Kitamura K., Kawai K., Tamaki N., Zhao S., Kuge Y., Asada Y.
PLoS ONE 12 ( 4 ) e0175976 2017年4月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：PLoS ONE
Diabetes mellitus accelerates atherosclerosis that causes most cardiovascular events. Several metabolic pathways are considered to contribute to the development of atherosclerosis, but comprehensive metabolic alterations to atherosclerotic arterial cells remain unknown. The present study investigated metabolic changes and their relationship to vascular histopathological changes in the atherosclerotic arteries of rabbits with alloxaninduced diabetes. Diabetic atherosclerosis was induced in rabbit ilio-femoral arteries by injecting alloxan (100 mg/kg), injuring the arteries using a balloon, and feeding with a 0.5% cholesterol diet. We histologically assessed the atherosclerotic lesion development, cellular content, pimonidazole positive-hypoxic area, the nuclear localization of hypoxiainducible factor-1α, and apoptosis. We evaluated comprehensive arterial metabolism by performing metabolomic analyses using capillary electrophoresis-time of flight mass spectrometry. We evaluated glucose uptake and its relationship to vascular hypoxia using 18F-fluorodeoxyglucose and pimonidazole. Plaque burden, macrophage content, and hypoxic areas were more prevalent in arteries with diabetic, than non-diabetic atherosclerosis. Metabolomic analyses highlighted 12 metabolites that were significantly altered between diabetic and non-diabetic atherosclerosis. A half of them were associated with glycolysis metabolites, and their levels were decreased in diabetic atherosclerosis. The uptake of glucose evaluated as 18F-fluorodeoxyglucose in atherosclerotic lesions increased according to increased macrophage content or hypoxic areas in non-diabetic, but not diabetic rabbits. Despite profound hypoxic areas, the nuclear localization of hypoxia-inducible factor-1α decreased and the number of apoptotic cells increased in diabetic atherosclerotic lesions. Altered glycolysis metabolism and an impaired response to hypoxia in atherosclerotic lesions under conditions of insulin-dependent diabetes might be involved in the development of diabetic atherosclerosis.
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Relationship between hemoglobin levels corrected by interdialytic weight gain and mortality in Japanese hemodialysis patients: Miyazaki dialysis cohort study. 査読あり
Toida T, Iwakiri T, Sato Y, Komatsu H, Kitamura K, Fujimoto S
PLoS One 12 ( 1 ) e0169117 2017年1月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Nishida T., Takeno S., Nakashima K., Kariya M., Inatsu H., Kitamura K., Nanashima A.
International Journal of Surgery Case Reports 36 155 - 160 2017年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：International Journal of Surgery Case Reports
Introduction Salvage surgery for locoregional failures after definitive chemoradiotherapy (dCRT) for esophageal cancer is widely practiced, but treatment options complementing it are also needed due to the high morbidity and mortality and low rate of curative resection. Presentation of case A 58-year-old man with a surgical history of right upper lobectomy for lung cancer was diagnosed as having esophageal squamous cell carcinoma. Computed tomography revealed swelling of the lesser curvature lymph node, and it had invaded the stomach, the body and tail of the pancreas and the left gastric artery, splenic artery and celiac artery. The patient underwent definitive-dose radiation with chemotherapy. Complete response was attained for the primary tumor, but the metastatic lymph node infiltrating the stomach, pancreas and major vessels remained. Therefore, the Appleby operation was proposed to the patient and subsequently performed aiming at curability. However, the primary tumor recurred 38 months after surgery, so the novel modality of photodynamic therapy using talaporfin sodium and a diode laser was performed, and a complete response was attained for this lesion. The patient is alive at 50 months after the salvage Appleby operation. Discussion and conclusion Salvage lymphadenectomy for esophageal cancer may be insufficient as a curative treatment because of regrowth of the primary lesion. However, photodynamic therapy may be applicable as a curative treatment option for recurrence of the primary lesion after salvage lymphadenectomy.
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Primary cardiac leiomyosarcoma: A 27-month survival with surgery and chemotherapy 査読あり
Nakashima K., Inatsu H., Kitamura K.
Internal Medicine 56 ( 16 ) 2145 - 2149 2017年
記述言語：英語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Internal Medicine
The patient was a 39-year-old man hospitalized due to the presence of a cardiac mass and heart failure. Emergency tumor resection and mitral valve replacement were performed. The pathological findings of the tumor led to a diagnosis of cardiac leiomyosarcoma. After the operation, multiple metastases were found. The patient underwent three courses of chemotherapies: adriamycin, ifosfamide, dacarbazine, and mesna (MAID therapy), gemcitabine plus docetaxel, and sunitinib. During MAID therapy, the patient underwent resection of gastrointestinal metastases twice due to gastrointestinal hemorrhaging. Although he died 27 months after the initial treatment, use of multimodal therapy was effective in achieving a longer survival for the patient.
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回腸結腸瘻を合併した虚血性小腸炎の1例 査読あり
伊豆本心太郎、仮屋暢人、山嶋友実、押川一達、宮後冴、久保衣里奈、三宮一朗、原口大、芦塚伸也、中島孝治、稲津東彦、北村和雄
日本消化器病学会九州支部例会プログラム・抄録集 109 164 - 164 2017年
掲載種別：研究論文（学術雑誌）
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FOLFIRI + Panitumumab療法を行った虫垂杯細胞カルチノイドの1例 査読あり
畑田絋志、山嶋友実、篠原実成、押川一達、米澤玲美、仮屋暢人、三宮一朗、松本英丈、中島孝治、芦塚伸也、稲津東彦、北村和雄、宮崎康幸、市原明子、池田拓人、大栗伸行、阿萬紫、佐藤勇一郎、河上洋
日本消化器病学会九州支部例会プログラム・抄録集 110 153 - 153 2017年
掲載種別：研究論文（学術雑誌）