論文 - 北村 和雄
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Phosphorylation of myocardial fructose-6-phosphate,2-kinase: fructose-2,6-bisphosphatase by cAMP-dependent protein kinase and protein kinase C. Activation by phosphorylation and amino acid sequences of the phosphorylation sites 査読あり
K Kitamura , K Kangawa, H Matsuo, K Uyeda
J Biol Chem 15 ( 263（32） ) 16796 - 16801 1988年11月
掲載種別：研究論文（学術雑誌）
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Isozymes of fructose 6-phosphate,2-kinasefructose-2,6-bisphosphatase in rat and bovine heart, liver, and skeletal muscle 査読あり
M Taniyama , K Kitamura, H Thomas, J W Lawson, K Uyeda
Biochem Biophys Res Commun 30 ( 157（3） ) 949 - 954 1988年10月
掲載種別：研究論文（学術雑誌）
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Immunoreactive neuromedin B and neuromedin C distribution and molecular heterogeneity in rat and human tissue extracts 査読あり
A Sakamoto , K Kitamura, Y Haraguchi, T Yoshida, K Tanaka
Am J Gastroenterol 82 ( 10 ) 1035 - 1041 1987年10月
掲載種別：研究論文（学術雑誌）
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Plasma concentration of human atrial natriuretic polypeptide in patients with impaired renal function 査読あり
Y Yamamoto, T Higa, K Kitamura, K Tanaka, K Kangawa, H Matsuo
Clin Nephrol 27 ( 2 ) 84 - 86 1987年2月
掲載種別：研究論文（学術雑誌）
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The mechanism of activation of heart fructose 6-phosphate,2-kinasefructose-2,6-bisphosphatase 査読あり
K Kitamura, K Uyeda
J Biol Chem 15 ( 262（2） ) 679 - 681 1987年1月
掲載種別：研究論文（学術雑誌）
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Plasma concentration of atrial natriuretic polypeptide in chronic hemodialysis patients 査読あり
Y Yamamoto, T Higa, K Kitamura, K Tanaka, K Kangawa, H Matsuo
Clin Nephrol 27 ( 2 ) 84 - 6 1987年
掲載種別：研究論文（学術雑誌）
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Higa T., Kitamura K., Tanaka K., Miyata A., Kangawa K., Matsuo H.
Japanese Circulation Journal 49 ( 9 ) 973 - 979 1985年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Japanese Circulation Journal
The cardiac content and plasma concentration of atrial natriuretic polypeptide (ANP) in hypertensive rats were measured by using radioimmunoassay for ANP. The animals used in this study were young (5-week-old) and adult (12- to 14-week-old) spontaneously hypertensive rats (SHR), stroke- prone SHR (SHR-SP) and normotensive control Wistar-Kyoto rats (WKY). Most immunoreactive ANP in the cardiac extract of the hypertensive rats (both SHR and SHR-SP) was found to be predominantly γ-form as well as that of WKY. Cardiac ANP content in adult SHR and SHR-SP was significantly lower than in adult WKY (p < 0.01), although there were no differences among three groups in young rats. Similar tendencies were also observed for plasma ANP concentration. The level of plasma in adult hypertensive rats was significantly lower or tended to be lower than in adult normotensive rats. Furthermore, a high negative correlation was present between blood pressure and cardiac ANP content (r = -0.748, p < 0.01) and between blood pressure and plasma ANP concentration (r = -0.608, p < 0.01) in all adult rats but there were no such relationships in young rats. The present study suggests that atrial natriuretic polypeptide may contribute to the pathogenesis or maintenance of high blood pressure in the genetic hypertensive rats. © 1985, The Japanese Circulation Society. All rights reserved.
DOI： 10.1253/jcj.49.973
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Plasma concentration of atrial natriuretic polypeptide in chronic hemodialysis patients 査読あり
Y Yamamoto, T Higa, K Kitamura, K Tanaka, K Kangawa, H Matsuo
Regul Pept Suppl 4 110 - 112 1985年
掲載種別：研究論文（学術雑誌）
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Regional distribution of β-neo-endorphin in rat brain and pituitary 査読あり
Kitamura K., Minamino N., Hayashi Y., Kangawa K., Matsuo H.
Biochemical and Biophysical Research Communications 109 ( 3 ) 966 - 974 1982年12月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Biochemical and Biophysical Research Communications
A highly specific and sensitive radioimmunoassay for β-neo-endorphin was developed, by using an antiserum against β-neo-endorphin. With this assay, the regional distribution of β-neo-endorphin was determined in rat brain and pituitary, and compared with that of α-neo-endorphin, which was assayed in the same samples. β-Neo-endorphin was found to be concentrated in the pituitary, especially in the posterior lobe, like α-neo-endorphin. β-Neo-endorphin was also widely distributed in brain, but in a different manner than α-neo-endorphin. Remarkable differences were observed in hippocampus, striatum and cortex, where α-neo-endorphin was found to predominate over β-neo-endorphin. The fact suggests that both peptides, although they are structurally related, possess different physiological functions. © 1982.
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腸管に存在するエンケフアリン関連ペプチド 査読あり
北村和雄、松尾寿之
日本内分泌学会雑誌 秋季大会抄録号 58 ( suppl-1 ) 1180 - 1180 1982年
掲載種別：研究論文（学術雑誌）
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Regional distribution of α-neo-endorphin in rat brain and pituitary 査読あり
Minamino N., Kitamura K., Hayashi Y., Kangawa K., Matsuo H.
Biochemical and Biophysical Research Communications 102 ( 1 ) 226 - 234 1981年9月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Biochemical and Biophysical Research Communications
α-Neo-endorphin was isolated as the first form of "big" Leu-enkephalin and its complete amino acid sequence has recently been established. Using an antiserum raised against synthetic α-neo-endorphin, a highly sentitive and specific radioimmunoassay was developed. The antiserum practically possesses no cross-reactivity to Leu-enkephalin, dynorphin[1-13] and PH-8P, and very little to β-neo-endorphin. Distribution of α-neo-endorphin has been determined in rat brain and pituitary by the use of the highly specific antiserum. The highest concentration was observed at posterior lobe of pituitary. Furthermore, immunoreactive α-neo-endorphin was characterized by gel-filtration and high performance liquid chromatography, and shown to be identical with authentic α-neo-endorphin. © 1981.
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REGIONAL DISTRIBUTION OF IMMUNOREACTIVE BIG LEU-ENKEPHALINS IN BRAIN AND PITUITARY 査読あり
N.MinaminoY.HayashiK.KitamuraH.MatsuoK.Kangawa
Proceedings of the International Narcotic Research Conference (Satellite Symposium of the 8th International Congress of Pharmacology) Held in Kyoto 26 ( 30 ) 160 - 162 1981年7月
掲載種別：研究論文（学術雑誌）