論文 - 北村 和雄
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Plasma Concentration of Human Brain Natriuretic Peptide in Patients on Hemodialysis 査読あり
Ishizaka Y., Yamamoto Y., Fukunaga T., Yokota N., Kida O., Kitamura K., Kangawa K., Minamino N., Matsuo H., Eto T.
American Journal of Kidney Diseases 24 ( 3 ) 461 - 472 1994年
掲載種別：研究論文（学術雑誌） 出版者・発行元：American Journal of Kidney Diseases
The plasma concentration of immunoreactive human brain natriuretic peptide (ir-BNP) was measured in 40 patients on hemodialysis (HD) and in 12 healthy subjects. Immunoreactive human atrial natriuretic peptide (ir-ANP) was also measured. The mean (+SE) plasma it-BNP concentration in the patients before HD (18.4 + 3.4 fmol/mL) was markedly higher than that in the control group (0.39 ± 0.08 fmol/mL). The plasma it-BNP level was significantly decreased by HD from 18.4 ± 3.4 fmol/mL to 10.5 ± 2.2 fmol/mL (P < 0.001), but the latter value was still higher than the upper limit of the normal range for our laboratory. There were significant correlations between the plasma it-ANP level and the mean blood pressure before HD (P < 0.05) and between the HD-induced changes in plasma it-ANP level and mean blood pressure (P < 0.001). These correlations were not observed between the plasma it-BNP level and mean blood pressure. The plasma it-BNP level correlated with the cardiothoracic ratio and this correlation was closer to that between the plasma ir-ANP level and cardiothoracic ratio. Ultrasound echocardiographic studies in 13 patients revealed that the pre-HD state of high cardiac output was corrected by HD in association with decreases in plasma ir-BNP and ir-ANP levels. Correlations were observed between the pre-HD it-ANP level and the interventricular septal thickness index (r = 0.68, P < 0.05) and between the change in it-BNP level and that in left atria) diameter (r = 0.806, P < 0.001). In conclusion, BNP levels were high in HD patients compared with the control subjects and were decreased during HD. In addition, BNP and ANP levels correlated with several parameters of volume change and cardiac status. © 1994, National Kidney Foundation. All rights reserved. All rights reserved.
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Pheochromocytoma associated with nocturnal hypertension 査読あり
Y Ishiyama 1, T Ohgi, T Kita, A Sasaki, K Kitamura, O Kida, T Kawasaki, T Eto
Intern Med . 32 ( 10 ) 781 - 783 1993年10月
掲載種別：研究論文（学術雑誌）
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Vasodilator effect of adrenomedullin and calcitonin gene-related peptide receptors in rat mesenteric vascular beds 査読あり
C Nuki 1, H Kawasaki, K Kitamura, M Takenaga, K Kangawa, T Eto, A Wada
Biochem Biophys Res Commun . 15 ( 196（1） ) 245 - 251 1993年10月
掲載種別：研究論文（学術雑誌）
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Hemodynamic effects of a novel hypotensive peptide, human adrenomedullin, in rats 査読あり
Y Ishiyama 1, K Kitamura, Y Ichiki, S Nakamura, O Kida, K Kangawa, T Eto
Eur J Pharmacol . 14 ( 241（2-3） ) 271 - 273 1993年9月
掲載種別：研究論文（学術雑誌）
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Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide 査読あり
J Sakata 1, T Shimokubo, K Kitamura, S Nakamura, K Kangawa, H Matsuo, T Eto
Biochem Biophys Res Commun . 15 ( 195（2） ) 245 - 251 1993年9月
掲載種別：研究論文（学術雑誌）
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Alterations in circulating and cardiac tissue concentrations of brain natriuretic peptide in spontaneously hypertensive rats 査読あり
N Yokota 1, Y Yamamoto, K Kitamura, K Kangawa, N Minamino, H Matsuo, T Eto
Cardiovasc Res . 27 ( 7 ) 1312 - 1315 1993年7月
掲載種別：研究論文（学術雑誌）
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Dimeric form of calcitonin gene-related peptide in the porcine thyroid gland 査読あり
Y Ichiki 1, K Kitamura, K Kangawa, T Eto
Biochem Biophys Res Commun . 31 ( 191（3） ) 961 - 967 1993年3月
掲載種別：研究論文（学術雑誌）
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Platelet neuropeptide Y in spontaneously hypertensive rats 査読あり
T Ogawa 1, K Kitamura, K Kangawa, H Matsuo, T Eto
J Hypertens . 10 ( 8 ) 765 - 771 1992年8月
掲載種別：研究論文（学術雑誌）
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Organ distribution and characterization of porcine peptides (VIP, CGRP and PHI) that increase cAMP in rat platelets 査読あり
Y Ichiki 1, K Kitamura, K Kangawa, M Kawamoto, H Matsuo, T Eto
Biochem Biophys Res Commun 30 ( 187（3） ) 1587 - 1593 1992年7月
掲載種別：研究論文（学術雑誌）
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Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma 査読あり
K Kitamura 1, K Kangawa, M Kawamoto, Y Ichiki, H Matsuo, T Eto
Biochem Biophys Res Commun 29 ( 185（1） ) 134 - 141 1992年5月
掲載種別：研究論文（学術雑誌）
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Immunoreactive endothelin in human kidney 査読あり
S Morita 1, K Kitamura, Y Yamamoto, T Eto, Y Osada, A Sumiyoshi, M Koono, K Tanaka
Ann Clin Biochem 28 ( Pt 3 ) 267 - 271 1991年5月
掲載種別：研究論文（学術雑誌）
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Increased secretion of brain natriuretic peptide and atrial natriuretic peptide, but not sufficient to induce natriuresis in rats with nephrotic syndrome 査読あり
N Yokota 1, Y Yamamoto, M Aburaya, K Kitamura, T Eto, K Kangawa, N Minamino, H Matsuo, K Tanaka
Biochem Biophys Res Commun 15 ( 174（1） ) 128 - 135 1991年1月
掲載種別：研究論文（学術雑誌）
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Renal tubular lesions induced by human Bence Jones protein in the rat N-acetyl-beta-D-glucosaminidase as a sensitive marker 査読あり
N Yokota 1, Y Yamamoto, K Kitamura, N Kuroki, S Hisanaga, S Fujimoto, T Eto, K Tanaka
Int J Exp Pathol 72 ( 3 ) 255 - 262 1991年1月
掲載種別：研究論文（学術雑誌）
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ネフローゼラットの心臓におけるneuropeptide Y(ir-NPY)およびir-ANP含量の検討 査読あり
家村文夫、横田直人、北村和雄、山本良髙、江藤胤尚
日本内分泌学会雑誌 67 ( 4 ) 375 - 375 1991年
掲載種別：研究論文（学術雑誌）
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Cardiac content of brain natriuretic peptide in DOCA salt-hypertensive rats 査読あり
N Yokota 1, M Aburaya, Y Yamamoto, J Kato, K Kitamura, O Kida, T Eto, N Minamino, K Kangawa, H Matsuo
Life Sci 48 ( 5 ) 397 - 402 1991年
掲載種別：研究論文（学術雑誌）
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Preferential increase in the free form of atrial natriuretic peptide in adriamycin-induced nephrotic rats 査読あり
N Yokota 1, J Kato, Y Yamamoto, K Kitamura, O Kida, T Eto, K Tanaka
Nephron 59 ( 1 ) 61 - 65 1991年
掲載種別：研究論文（学術雑誌）
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Increased plasma brain natriuretic peptide levels in DOCA-salt hypertensive rats relation to blood pressure and cardiac concentration 査読あり
Biochem Biophys Res Commun
N Yokota 1, M Aburaya, Y Yamamoto, J Kato, K Kitamura, O Kida, T Eto, N Minamino, K Kangawa, H Matsuo, 14 ( 173（2） ) 632 - 638 1990年10月
掲載種別：研究論文（学術雑誌）
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Distribution and molecular form of immunoreactive big endothelin-1 in porcine tissue 査読あり
K Kitamura 1, T Yukawa, S Morita, Y Ichiki, T Eto, K Tanaka
Biochem Biophys Res Commun 31 ( 170（2） ) 497 - 503 1990年7月
掲載種別：研究論文（学術雑誌）
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Isolation of NPY-25 (neuropeptide Y[12-36]), a potent inhibitor of calmodulin, from porcine brain 査読あり
K Kitamura 1, K Kangawa, K Tanaka, H Matsuo
Biochem Biophys Res Commun . 29 ( 169（3） ) 497 - 503 1990年6月
掲載種別：研究論文（学術雑誌）
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Chromatographic characterization of immunoreactive endothelin in rat lung 査読あり
K Kitamura , T Tanaka, J Kato, T Eto, K Tanaka
Life Sci 46 ( 6 ) 405 - 409 1990年
掲載種別：研究論文（学術雑誌）