論文 - 北村 和雄
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新規アンジオテンシンペプチドとは：ビッグアンジオテンシン-25と組織レニン・アンジオテンシン系 査読あり
永田さやか、北村和雄
比較内分泌学 41 156 - 156 2015年9月
掲載種別：研究論文（学術雑誌）
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Bench-to-bedside pharmacology of adrenomedullin 査読あり
Kato J., Kitamura K.
European Journal of Pharmacology 764 140 - 148 2015年7月
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：European Journal of Pharmacology
The bioactive peptide adrenomedullin (AM) exerts pleiotropic actions in various organs and tissues. In the heart, AM has an inhibitory effect on ventricular remodeling, suppressing cardiomyocyte hypertrophy and the proliferation of cardiac fibroblasts. This pharmacological property was shown not only in rat models of acute myocardial infarction, but also clinically in patients with this cardiac disease. An originally characterized feature of AM was a potent vasodilatory effect, but this peptide was found to be important for vascular integrity and angiogenesis. AM-induced angiogenesis is involved in tumor growth, while AM inhibits apoptosis of some types of tumor cell. A unique pharmacological property is anti-inflammatory activity, which has been characterized in sepsis and inflammatory bowel diseases; thus, there is an ongoing clinical trial to test the efficacy of AM for patients with intractable ulcerative colitis. These activities are assumed to be mediated via the specific receptor formed by calcitonin receptor-like receptor and receptor activity-modifying protein 2 or 3, while some questions remain to be answered about the molecular mechanisms of this signal transduction system. Taking these findings together, AM is a bioactive peptide with pleiotropic effects, with potential as a therapeutic tool for a wide range of human diseases from myocardial infarction to malignant tumors or inflammatory bowel diseases.
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Urine podocyte mRNAs mark disease activity in IgA nephropathy. 査読あり
Fukuda A, Sato Y, Iwakiri T, Komatsu H, Kikuchi M, Kitamura K, Wiggins RC, Fujimoto S.
Nephrology Dialysis Transplantation 30 ( 7 ) 1140 - 1150 2015年7月
記述言語：英語 掲載種別：研究論文（学術雑誌）
DOI： 10.1093/ndt/gfv104
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Yamaguchi M, Nishihira K, Okubo T, Asada Y, Kitamura K.
Internal Medicine 54 ( 10 ) 1243 - 1246 2015年5月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Effect of adrenomedullin administration in two rat models of experimental inflammatory bowel disease. 査読あり
Nagata S, Hikosaka T, Kitamura K
American Journal of Life Sciences 3 ( （３－２） ) 39 - 42 2015年5月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Differences in 24-h blood pressure profile of Japanese hypertensive patients under ARB treatment. 査読あり
Kita T, Sakima A, Yokota N, Tamaki N, Etoh T, Shimokubo T, Nakada S, Takishita S, Ohya Y, Kitamura K.
Clinical and Experimental Hypertension 37 ( 7 ) 574 - 579 2015年5月
記述言語：英語 掲載種別：研究論文（学術雑誌）
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Structure-function relationships between aldolase C/zebrin II expression and complex spike synchrony in the cerebellum 査読あり
I Sugihara
o Watanabe, Kenji Sakimura, Masanobu Kano, Kazuo KitaShinichiro Tsutsumi, Maya Yamazaki, Taisuke Miyazaki, Masahikmura 35 ( 2 ) 843 - 852 2015年1月
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Adrenomedullin as a Potential Therapeutic Agent for Refractory Ulcerative Colitis 査読あり
Kazuo Kitamura, Shinya Ashizuka, Haruhiko Inatsu, Toshihiro Kita
Innovative Medicine 227 - 240 2015年
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Gender-related alterations in plasma adrenomedullin level and its correlation with body weight gain 査読あり
Kawano S., Kawagoe Y., Kuwasako K., Shimamoto S., Igarashi K., Tokashiki M., Kitamura K., Kato J.
Endocrine Connections 4 ( 1 ) 43 - 49 2015年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Endocrine Connections
Plasmalevels of adrenomedullin(AM), a bioactivepeptide producedin adipose tissue,havebeen shown to be higher in obese patients than in non-obese patients, but little is known about gender differences in plasma AMlevels. The aims of this study were to clarify gender-related alterations in plasma AMlevels and to examine the body weight (BW) gain–plasma AM relationship in the general population.We measured plasma AMlevels of 346 local residents (62.0G8.9 years,meanGS.D.) intheKiyotakearea, Japan,whounderwentaregularhealthcheckup, by a specific fluorescence immunoassay. PlasmaAMlevels in the female residentswere lower than that in the males, and multiple regression analysis revealed a possible gender difference in plasma AM. The AM levels were significantly correlated with BMI or waist circumference in women, but such a relationship was not seen in men.When the subjects were divided into two groups by results of a questionnaire about BWgain of 10 kg or more since the age of 20 years, the plasmaAMlevel ofwomenwith BWgainS10 kgwas significantly higher than that in those without BW gain, although no difference was noted between the men with and without BW gain. In conclusion, possible gender differences were noted in the plasma AM levels and in the BWgain–plasmaAMrelationship in the general population. The plasmaAMlevels in the female residents without BW gain seem partly attributable to the lower AMof women.
DOI： 10.1530/EC-14-0131
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Matsuura Y., Yamashita A., Iwakiri T., Sugita C., Okuyama N., Kitamura K., Asada Y.
Thrombosis and Haemostasis 114 ( 1 ) 158 - 172 2015年
記述言語：日本語 掲載種別：研究論文（学術雑誌） 出版者・発行元：Thrombosis and Haemostasis
Atherosclerotic lesions represent a hypoxic milieu. However, the significance of this milieu in atherothrombosis has not been established. We aimed to assess the hypothesis that vascular wall hypoxia promotes arterial thrombus formation. We examined the relation between vascular wall hypoxia and arterial thrombus formation using a rabbit model in which arterial thrombosis was induced by 0.5 %- cholesterol diet and repeated balloon injury of femoral arteries. Vascular wall hypoxia was immunohistochemically detected by pimonidazole hydrochloride, a hypoxia marker. Rabbit neointima and THP-1 macrophages were cultured to analyse prothrombotic factor expression under hypoxic conditions (1 % O2). Prothrombotic factor expression and nuclear localisation of hypoxia-inducible factor (HIF)-1α and nuclear factor-kappa B (NF-κB) p65 were immunohistochemically assessed using human coronary atherectomy plaques. Hypoxic areas were localised in the macrophage-rich deep portion of rabbit neointima and positively correlated with the number of nuclei immunopositive for HIF-1α and NF-κB p65, and tissue factor (TF) expression. Immunopositive areas for glycoprotein IIb/IIIa and fibrin in thrombi were significantly correlated with hypoxic areas in arteries. TF and plasminogen activator inhibitor-1 (PAI-1) expression was increased in neointimal tissues and/or macrophages cultured under hypoxia, and both were suppressed by inhibitors of either HIF-1 or NF-κB. In human coronary plaques, the number of HIF-1α-immunopositive nuclei was positively correlated with that of NF-κB-immunopositive nuclei and TF-immunopositive and PAI-1-immunopositive area, and it was significantly higher in thrombotic plaques. Vascular wall hypoxia augments the thrombogenic potential of atherosclerotic plaque and thrombus formation on plaques via prothrombotic factor upregulation.
DOI： 10.1160/TH14-09-0794
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潰瘍性大腸炎に対するアドレノメデュリン療法, 長期経過の検討 査読あり
芦塚伸也、黒石頌子、久保絵里奈、増田稔、三木吾郎、彦坂ともみ、松本英丈、中島孝治、稲津東彦、北村和雄
日本消化器病学会雑誌 112 ( suppl-2 ) 937 - 937 2015年
掲載種別：研究論文（学術雑誌）
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アンジオテンシンII持続投与高血圧ラットの血圧変動性増大 査読あり
姜丹鳳、渡嘉敷真理子、林英孝、川越由紀子、桑迫健二、北村和雄、加藤丈司
日本内分泌学会雑誌 91 ( 2 ) 639 - 639 2015年
掲載種別：研究論文（学術雑誌）
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重度の低K血症を伴いながら正常血圧を呈した原発性アルドステロン症の1例 査読あり
渡辺雄佑、栗原勲、宮下和季、小林佐紀子、横田健一、中村俊文、井上博之、北村和雄、小黒草太、伊藤裕
日本内分泌学会雑誌 91 ( 2 ) 642 - 642 2015年
掲載種別：研究論文（学術雑誌）
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N端パルミトイル化アドレノメデュリン誘導体の生理活性に関して 査読あり
渡嘉敷真理子、久保恵是、桑迫健二、永田さやか、加藤丈司、北村和雄
日本内分泌学会雑誌 91 ( 2 ) 647 - 647 2015年
掲載種別：研究論文（学術雑誌）
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ApoE KOマウスの動脈硬化進展における血管外膜の炎症と陽性リモデリング 査読あり
坂元紀陽、鶴田敏博、畠山金太、今村卓郎、浅田祐士郎、北村和雄
日本内分泌学会雑誌 91 ( 2 ) 649 - 649 2015年
掲載種別：研究論文（学術雑誌）
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難治性小腸出血にオクトレオチドが有効であった2例 査読あり
久保衣里奈、黒石頌子、大野妙子、増田稔、三木吾郎、彦坂ともみ、松本英丈、芦塚伸也、中島孝治、稲津東彦、北村和雄
日本消化器病学会雑誌 112 ( suppl-2 ) 854 - 854 2015年
掲載種別：研究論文（学術雑誌）
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一般住民における血中アドレノメデュリン値の性差および体重増加との関連 査読あり
河野清香、川越由紀子、桑迫健二、島本怜史、五十嵐浩二、渡嘉敷真理子、北村和雄、加藤丈司
日本内分泌学会雑誌 91 ( 2 ) 647 - 647 2015年
掲載種別：研究論文（学術雑誌）
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新しいアンジオテンシン関連ペプチドであるビッグアンジオテンシン-25の測定系の確立 査読あり
永田さやか、福田顕弘、佐藤祐二、藤元昭一、井田隆徳、桑迫健二、渡嘉敷真理子、北村和雄
日本内分泌学会雑誌 91 ( 2 ) 643 - 643 2015年
掲載種別：研究論文（学術雑誌）
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新規アンジオテンシンペプチドの同定と機能解析 : ビッグアンジオテンシン-25 査読あり
永田さやか、北村和雄
Angiotensin Research 12 ( 2 ) 88 - 94 2015年
掲載種別：研究論文（学術雑誌）
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新たなアンジオテンシン関連ペプチド : ビッグアンジオテンシン-25 査読あり
永田さやか、北村和雄
日本内分泌学会雑誌 91 ( 1 ) 260 - 260 2015年
掲載種別：研究論文（学術雑誌）