Papers - CHOSA Etsuo
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Possible association of single nucleotide polymorphisms in the 3' untranslated region of HOXB9 with acetabular overcoverage(共著) Reviewed
T Sekimoto, S Kurogi, T Funamoto, T Ota, S Watanabe, T Sakamoto, H Hamada, E Chosa.
Bone & Joint Research 4 ( 4 ) 50 - 55 2015.4
Language：English Publishing type：Research paper (scientific journal)
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Sekimoto T., Kurogi S., Funamoto T., Ota T., Watanabe S., Sakamoto T., Hamada H., Chosa E.
Bone and Joint Research 4 ( 4 ) 50 - 55 2015.4
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Bone and Joint Research
© 2015 The British Editorial Society of Bone and Joint Surgery.Objectives: Excessive acetabular coverage is the most common cause of pincer-type femoroacetabular impingement. To date, an association between acetabular over-coverage and genetic variations has not been studied. In this study we investigated the association between single nucleotide polymorphisms (SNPs) of paralogous Homeobox (HOX)9 genes and acetabular coverage in Japanese individuals to identify a possible genetic variation associated with acetabular overcoverage. Methods: We investigated 19 total SNPs in the four HOX9 paralogs, then focused in detail on seven of those located in the 3' untranslated region of HOXB9 (rs8844, rs3826541, rs3826540, rs7405887, rs2303485, rs2303486, rs79931349) using a case-control association study. The seven HOXB9 SNPs were genotyped in 316 subjects who had all undergone radiological examination. The association study was performed by both single-locus and haplotypebased analyses. Results: The genotype and allele frequencies of the five HOXB9 SNPs showed significant association with acetabular over-coverage compared with controls (rs7405887 OR = 3.16, p = 5.29E-6, 95% CI 1.91 to 5.25). A significant difference was also detected when haplotypes were evaluated (OR = 2.59, p = 2.61E-5, 95% CI 1.65 to 4.08). The two HOXB9 SNPs (rs2303485, rs2303486) were associated with decreased acetabular coverage (rs2303485 OR = 0.524, p = 0.0091, 95% CI 0.322 to 0.855; rs2303486 OR = 0.519, p = 0.011, 95% CI 0.312 to 0.865). Conclusions: The five HOXB9 SNPs (rs8844, rs3826541, rs3826540, rs7405887, rs79931349) were associated with acetabular over-coverage. On the other hand, the two SNPs (rs2303485 and rs2303486) were associated with the lower acetabular coverage. The association of rs2303486 would be consistent with the previous study. Therefore, the HOXB9 SNPs might be involved in the morphogenesis of acetabular coverage, and could be an independent risk factor for developing pincer-type femoroacetabular impingement.
DOI： 10.1302/2046-3758.44
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多発性硬化症（MS）を合併した頚髄症に手術療法を施行した1例 Reviewed
濱中秀昭, 猪俣尚規, 比嘉聖, 永井琢哉, 山口洋一朗, 今里浩之, 帖佐悦男
整形外科と災害外科 64 ( 1 ) 25 - 28 2015.3
Language：Japanese Publishing type：Research paper (scientific journal)
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自家ハムストリング腱を用いたbi-socket法によるPCL再建術の術後短期成績 Reviewed
田島卓也, 河原勝博, 山口奈美, 石田康行, 谷口昇, 帖佐悦男
日本関節鏡・膝・スポーツ整形外科学会雑誌（JOSKAS） 40 ( 1 ) 176 - 177 2015.3
Language：Japanese Publishing type：Research paper (scientific journal)
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1A32 Biomechanical evaluation of Ganz ring in total hip arthroplasty
NAKAMURA Kosuke, YAMAKO Go, DENG Gang, OTSUKA Hiroki, TOTORIBE Koji, SAKAMOTO Takero, CHOSA Etsuo
2015 ( 27 ) 29 - 30 2015.1
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers
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2F23 Characteristics of hip joint contact for different gait patterns
OUCHI Koki, DENG Gang, YAMAKO Go, CHOSA Etsuo, TOTORIBE Koji
2015 ( 27 ) 523 - 524 2015.1
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Japan Society of Mechanical Engineers
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石田 康行, 帖佐 悦男, 矢野 浩明, 谷口 昇, 大田 智美, 中村 志保子
肩関節 39 ( 3 ) 783 - 786 2015
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Japan Shoulder Society
腱板断裂に伴った腋窩神経麻痺の多くが自然回復することから，早期の腱板修復術を推奨する報告がある．しかし，一次修復不能な断裂では治療方針に苦慮する．手術を行わなかった腋窩神経麻痺を伴った腱板広範囲断裂の経過を調査した．症例は5肩．年齢は69～79歳，経過観察期間12～44ヵ月であった．全例肩関節前方脱臼に伴った腱板広範囲断裂と腋窩神経麻痺であった．麻痺回復徴候を認めた時期，受傷前の自動挙上角度に回復した時期と，初診時と最終観察時のJOA scoreの疼痛，機能，可動域で調査した．全例，受傷前の挙上角度に回復し，麻痺回復徴候を認めた時期は2～6ヵ月，受傷前の挙上に回復した時期は5～12ヵ月であった．JOA scoreは初診時平均32.5点が最終観察時平均60.5点へ有意に改善していた．腋窩神経麻痺を伴った腱板断裂に対する手術は絶対適応ではなく，断裂腱板の状態で検討すべきと考える．
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小島 岳史, 黒田 宏, 岡村 龍, 松岡 篤, 帖佐 悦男
整形外科と災害外科 64 ( 4 ) 837 - 841 2015
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：West-Japanese Society of Orthopedics & Traumatology
腓骨遠位部骨折に伴う整復困難な足関節脱臼骨折であるBosworth骨折を2例経験し術後長期経過したので報告する．【症例1】18歳男性．交通外傷後近医に搬送．徒手整復できず直達牽引施行されたが整復不能．受傷5日目に当院紹介入院．同日腰麻下にORIF施行．術後4週で全荷重歩行開始し，術後10ヶ月で疼痛，可動域制限なく骨癒合得られ抜釘術を行った．術後9年でJSSF scale 100点であった．【症例2】53歳男性．2 mの高さより転落し受傷．同日腰麻下に，観血的整復術施行．受傷後10日目にORIF施行．術後6週で全荷重歩行とし，術後10ヶ月で疼痛，可動域制限なく骨癒合得られ抜釘術を行った．術後3年で軽度の不安定性を認めJSSF scale 92点であった．【考察】本症例は1947年にBosworthが報告した腓骨遠位部骨折を伴った足関節の脱臼骨折で，腓骨近位骨片が脛骨後方に転位し固定され整復が障害されるものである．Lauge-HansenのSupination-External rotation損傷（以下SER損傷）と診断してしまうと，初期治療を誤る可能性があり注意が必要である．
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Takahashi S., Fukushima W., Yamamoto T., Iwamoto Y., Kubo T., Sugano N., Hirota Y., Matsuno T., Ito H., Kishida S., Nakamura J., Nakamura Y., Kishiya M., Yasunaga Y., Yamasaki T., Takahashi D., Asano T., Majima T., Komiya S., Ishidou Y., Arishima Y., Kabata T., Matsumoto T., Kaneuji A., Ohzono K., Itoman M., Nishiyama T., Fujishiro T., Higuchi F., Okawa T., Fujioka M., Ueshima K., Motomura G., Sudo A., Chosa E., Osaki M., Hasegawa Y., Endo N., Tokunaga K., Kaku N., Nishii T., Sakai T., Takao M., Takaoka K., Nakamura H., Iwaki H., Miki H., Hotokebuchi T., Mawatari M., Ninomiya S., Taneda H., Nagoya S., Kodaira H., Atsumi T., Kobayashi S., Tanaka S., Ito H., Yamamoto K., Jinno T., Koga D., Takagi M., Sasaki K., Inaba Y., Kobayashi N.
Journal of Epidemiology 25 ( 6 ) 437 - 444 2015
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Journal of Epidemiology
© 2015 Shinji Takahashi et al. Background: Nontraumatic osteonecrosis of the femoral head (ONFH) is a rare disorder caused by ischemic necrosis of unknown etiology. A few studies have demonstrated trends in the number of patients with ONFH. However, there are no data on temporal trends in characteristics such as age, gender, and causative factors. To investigate this, we examined data from a multicenter hospital-based sentinel monitoring system in Japan. Methods: A total of 3041 newly-diagnosed ONFH patients from 34 participating hospitals who were reported to the system from 1997-2011 were analyzed. We examined age at diagnosis, potential causative factors, and underlying diseases for which patients received systemic steroid administration. Their temporal trends were assessed according to date of diagnosis in 5-year intervals (1997-2001, 2002-2006, and 2007-2011). Results: The gender ratio and distribution of potential causative factors did not change. Regarding underlying diseases requiring steroid administration, the proportion of patients with systemic lupus erythematosus decreased in males (10% to 6.4%) and in females (37% to 29%). Proportion of patients with renal transplantation fell consistently across the study period in both males (3.8% to 1.2%) and females (3.2% to 0.8%). In contrast, the proportion of patients receiving steroids for pulmonary disease (except asthma) significantly increased in both males (0.5% to 5.5%) and females (0.5% to 3.6%). Conclusions: This large descriptive study is the first to investigate temporal trends in the characteristics of ONFH, which provide useful information for future studies.
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Prospective Comparisons of Femoral Tunnel Enlargement With 3 Different Postoperative Immobilization Periods After Double-Bundle Anterior Cruciate Ligament Reconstruction With Hamstring Grafts. Reviewed
Tajima T, Chosa E, Kawahara K, Yamaguchi N.
Arthroscopy 864 - 870 2014.12
Language：English Publishing type：Research paper (scientific journal)
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Bone marow stimulation at the footprint of arthroscopic surface-holding repair advances cuff repair integrity.(共著) Reviewed
Taniguchi N, Suenaga N, Oizumi N, Miyoshi N, Yamaguchi H, Inoue K, Chosa E.
Journal of Shoulder and Elbow Surgery 24 ( 6 ) 860 - 866 2014.12
Language：English Publishing type：Research paper (scientific journal)
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検診で発見された上腕骨小頭離断性骨軟骨炎の特徴 Reviewed
石田 康行, 帖佐 悦男, 矢野 浩明, 山口 奈美, 大田 智美, 中村 志保子
日本肘関節学会雑誌 21 ( 2 ) 177 - 180 2014.12
Language：Japanese Publishing type：Research paper (scientific journal)
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In-vitro biomechanical evaluation of stress shielding and initial stability of a low-modulus hip stem made of β type Ti-33.6Nb-4Sn alloy. Reviewed
Yamako G, Chosa E, Totoribe K, Hanada S, Masahashi N, Yamada N, Itoi E.
Medical Engineering & Physics 1665 - 1671 2014.12
Language：English Publishing type：Research paper (scientific journal)
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Comprehensive Safety Manegement and Assessment at Rugby Football Competitions. Invited Reviewed
Tajima T, Chosa E, Kawahara K, Nakamura Y, Yoshikawa D, Yamaguchi N, Kashiwagi T.
International Journal of sports medicine 35 1012 - 1016 2014.12
Language：English Publishing type：Research paper (scientific journal)
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Medical check up for youth baseball players in Miyazaki. Reconsideration and improvement. Invited Reviewed
Journal of Joint Surgery 33 ( 11 ) 86 - 91 2014.11
Language：Japanese Publishing type：Research paper (scientific journal)
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Treatment of osteochondritis dissecans of humeral capitellum Invited Reviewed
Journal of Joint Surgery 33 ( 11 ) 39 - 43 2014.11
Language：Japanese Publishing type：Research paper (scientific journal)
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肩関節 Invited Reviewed
石田康行, 宮﨑茂明, 帖佐悦男
Monthy Book Medical Rehabilitation 176 87 - 95 2014.11
Language：Japanese Publishing type：Research paper (scientific journal)
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腰痛・膝痛のリハビリテーション Invited Reviewed
.帖佐悦男
臨床と研究 91 ( 11 ) 1460 - 1464 2014.11
Language：Japanese Publishing type：Research paper (scientific journal)
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Chronic sports injuries of the pelvis,hip and thigh Invited Reviewed
4 ( 4 ) 633 - 640 2014.10
Language：Japanese Publishing type：Research paper (scientific journal)
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在宅ロコモ対策支援（ロコモコール）の意義と効果 Invited Reviewed
帖佐悦男, 中村耕三, 藤野圭司, 安村誠司, 高岸憲二, 石田健司, 遠藤直人, 石橋英明, 千田益生, 島田洋一, 阿久根徹
整形・災害外科 57 ( 11 ) 1433 - 1439 2014.10
Language：Japanese Publishing type：Research paper (scientific journal)