Papers - CHOSA Etsuo
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Safe and Simple Techniques for Cervical Pedicle Screw Insertion
KUBO Shinichiro
19 ( 4 ) 719 - 723 2008.12
Language：Japanese Publishing type：Research paper (scientific journal)
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帖佐 悦男
臨床スポーツ医学 = The journal of clinical sports medicine 25 ( 12 ) 1343 - 1344 2008.12
Language：Japanese Publishing type：Research paper (scientific journal)
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安全かつ簡便な頸椎椎弓根スクリューの刺入手技（共著） Reviewed
久保紳一郎, 帖佐悦男, 黒木浩史, 花堂祥治, 濱中秀昭
日本脊椎脊髄病学会雑誌 19 ( 4 ) 719 - 723 2008.12
Language：Japanese Publishing type：Research paper (scientific journal)
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皮切にこだわらないMIS人工股関節置換術（共著） Reviewed
帖佐悦男, 坂本武郎, 渡邊信二, 関本朝久, 濱田浩朗, 前田和徳, 野﨑正太郎, 中村嘉宏, 舩元太郎, 柏木輝行
Hip Joint 34 479 - 482 2008.11
Language：Japanese Publishing type：Research paper (scientific journal)
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臼蓋形成不全症におけるSNP解析（共著） Reviewed
関本朝久, 帖佐悦男, 舩元太郎, 濱田浩朗, 坂本武郎, 渡邊信二, 野﨑正太郎, 前田和徳, 中村嘉宏
Hip Joint 34 520 - 523 2008.11
Language：Japanese Publishing type：Research paper (scientific journal)
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SNP finding analysis of the acetabular dysplasia
SEKIMOTO Tomohisa
34 520 - 523 2008.11
Language：Japanese Publishing type：Research paper (scientific journal)
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Thurapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits. "jointly worked" Reviewed
Toshiyuki Okura, Kousuke Marutsuka, Hiroaki Hamada, Tomohisa Sekimoto, Tsuyoshi Fukushima, Yujiro Asada, Kazuo Kitamura, Etsuo Chosa
Arthritis Research & Therapy 10 ( 6 ) R133 - R142 2008.11
Language：English Publishing type：Research paper (scientific journal)
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Okura T., Marutsuka K., Hamada H., Sekimoto T., Fukushima T., Asada Y., Kitamura K., Chosa E.
Arthritis Research and Therapy 10 ( 6 ) R133 2008.11
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Arthritis Research and Therapy
Introduction: Adrenomedullin is a potent vasodilatory and hypotensive peptide as well as an endogenous immunomodulatory factor with predominantly anti-inflammatory effects. The purpose of the present study was to evaluate the therapeutic effects of adrenomedullin in rabbits with antigen-induced arthritis, an experimental model of rheumatoid arthritis. Methods: Following the induction of arthritis in both knee joints by ovalbumin injection into the joint spaces of pre-immunized rabbits, increasing daily doses of adrenomedullin were injected into the knee joint spaces or saline was injected into the contralateral knee joint spaces as the control. For time-course experiments, adrenomedullin and saline were injected into the knee joint spaces daily for 7 days and 20 days. The degree of joint swelling and the histological change in the knee joints injected with adrenomedullin were compared with the control knee joints. Histological evaluation of the infrapatellar fat pads and synovial tissue was performed. TNFα, IL-6, vascular endothelial growth factor and transforming growth factor-beta mRNA levels in the synovial tissue were measured using real-time quantitative PCR. Results: Daily injections of adrenomedullin into the knee joint spaces of rabbits with antigen-induced arthritis decreased joint swelling. Histological examination revealed that adrenomedullin reduced edematous changes and the infiltration of inflammatory cells in the synovial tissues. Analysis of mRNA levels showed that adrenomedullin significantly reduced TNFα mRNA expression by 21% to 49% in a dose-dependent manner, and dose-dependently increased IL-6 mRNA expression by 45% to 121%. Conclusions: These results suggest that daily injections of adrenomedullin into the knee joint spaces of rabbits with antigen-induced arthritis ameliorated the inflammatory response in arthritic joints. Adrenomedullin may thus be useful as a treatment for rheumatoid arthritis; however, the effect of adrenomedullin on IL-6 production in the synovial tissue may be an undesirable adverse effect in rheumatoid arthritis therapy. © 2008 Okura et al.; licensee BioMed Central Ltd.
DOI： 10.1186/ar2550
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3次元有限要素法による肩関節の応力解析（共著） Reviewed
井上 篤, 後藤啓輔, 田島直也, 帖佐悦男
日本臨床バイオメカニクス学会誌 29 77 - 80 2008.11
Language：Japanese Publishing type：Research paper (scientific journal)
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Finite element analysis on the acetabular labrum Reviewed
Koji TOTORIBE,MD.,Etsuo CHOSA,MD.,Xin ZHAO,Shinji WATANABE,MD.,Gang DENG,PhD.
29 317 - 320 2008.11
Language：Japanese Publishing type：Research paper (scientific journal)
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Finite element analysis on the acetabular head coverage Reviewed
Xin ZHAO,Etsuo CHOSA,MD.,KojiTOTORIBE,MD.,Shinji WATANABE,MD.,GangDENG,PhD.
29 321 - 324 2008.11
Language：Japanese Publishing type：Research paper (scientific journal)
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Stress analysis of the glenohumeral joint using the three-dimensional finite element method
INOUE Atsushi, GOTO Keisuke, TAJIMA Naoya, CHOSA Etsuo
29 77 - 80 2008.11
Language：Japanese Publishing type：Research paper (scientific journal)
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Orthopaedic medical care in the provinces in the near future Reviewed
The Journal of the Japanese Orthopaedic Association 82 ( 10 ) 868 - 870 2008.10
Language：Japanese Publishing type：Research paper (scientific journal)
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【上肢の外科 最近の進歩】手関節・手疾患の治療 母指手根中手変形性関節症の治療 母指手根中手関節症に対する固定術の経験（共著） Reviewed
﨑濵智美, 矢野浩明, 帖佐悦男
別冊整形外科 ( 54 ) 199 - 202 2008.10
Language：Japanese Publishing type：Research paper (scientific journal)
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腰痛症に対するジブカイン塩酸塩配合薬によるトリガーポイント注射の治療効果（共著） Reviewed
公文崇詞, 久保伸一郎, 黒木浩史, 濱中秀昭, 帖佐悦男
整形・災害外科 51 ( 11 ) 1477 - 1481 2008.10
Language：Japanese Publishing type：Research paper (scientific journal)
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Komaki W., Komaki W., Fukushima T., Tanaka H., Itoh H., Chosa E., Kataoka H.
Virchows Archiv 453 ( 4 ) 347 - 357 2008.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Virchows Archiv
Hepatocyte growth factor activator inhibitor type 1 (HAI-1)/spint-1 is a membrane-bound protease inhibitor that is thought to regulate the activities of hepatocyte growth factor activator, matriptase, hepsin, and prostasin. In this study, we show that the membrane form of HAI-1 was significantly upregulated immunohistochemically in epithelial cells under adverse conditions including tissue injury, necroinflammatory reactions, and invasion of carcinomas. To analyze the mechanism underlying these in vivo observations, we examined the effects of hypoxia and oxidative stress on HAI-1 expression in vitro, using three human cell lines, HLC-1, WiDr, and HeLa. Hypoxic condition significantly enhanced the expression of HAI-1 in these cells. Oxidative stress also enhanced HAI-1 expression. Promoter analyses of the human HAI-1/spint-1 gene revealed overlapping binding site for Egr-1-3 and Sp1 near the transcription start site as the key domain for HAI-1/spint-1 transcription. This site was also critical in both hypoxic- and oxidative stress-induced HAI-1 upregulation. In fact, in vivo immunohistochemical studies indicated that areas with HAI-1 upregulation tended to express markers associated with hypoxia and oxidative stress. These observations suggest that the tissue microenvironment regulates the cell surface expression of HAI-1, and thereby may regulate proteolysis and processing of bioactive molecules on the cellular surface. © 2008 Springer-Verlag.
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Lumbar Ligamentum Flavum Hematoma : A Case Report
KOJIMA Takeshi, KUROKI Hiroshi, HAMANAKA Hideaki, KUBO Shinichiro, HANADO Shoji, INOMATA Naoki, KIRIYA Riki, FUKUSHIMA Katsuhiko, KOMAKI Wataru, CHOSA Etsuo
57 ( 4 ) 567 - 571 2008.9
Language：Japanese Publishing type：Research paper (scientific journal)
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Expression of hepatocyte growth factor inhibitor type 1 on the epithelial cellsurface is regulated by hypoxic and oxidative. "jointly worked" Reviewed
Wataru Komaki, Tsuyoshi Fukushima, Hiroyuki Tanaka, Hiroshi Itoh, Etsuo Chosa, Hiroaki Kataoka
Virchows Arch 453 347 - 357 2008.9
Language：English Publishing type：Research paper (scientific journal)
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腰椎黄色靭帯内血腫の1例（共著） Reviewed
小島岳史, 黒木浩史, 濱中秀昭, 久保紳一郎, 花堂祥治, 猪俣尚規, 桐谷 力, 福島克彦, 小牧 亘, 帖佐悦男
整形外科と災害外科 57 ( 4 ) 567 - 571 2008.9
Language：Japanese Publishing type：Research paper (scientific journal)
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反復性肩関節脱臼を呈する骨性Bankart病変に対する鏡視下修復術 Reviewed
石田康行, 帖佐悦男, 矢野浩明, 山本惠太郎, 河原勝博, 田島卓也, 﨑濵智美, 三橋龍馬
宮崎県医師会医学会誌 32 ( 2 ) 78 - 85 2008.9
Language：Japanese Publishing type：Research paper (scientific journal)