Papers - CHOSA Etsuo
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医療広告はどうあるべきか Reviewed
帖佐 悦男
整形外科と災害外科 48 ( 1 ) 1 - 1 2005.1
Language：Japanese Publishing type：Research paper (scientific journal)
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Evaluation of Circulatory Compromise in the Leg in Lumbar Spinal Canal Stenosis Reviewed
帖佐 悦男,関本 朝久,久保 紳一郎,田島 直也
Clin Orthop Relat Res. 431 129 - 33 2005.2
Language：English Publishing type：Research paper (scientific journal)
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再生医療としての骨切り術 Reviewed
帖佐 悦男
臨床整形外科 40 ( 3 ) 229 - 230 2005.3
Language：Japanese Publishing type：Research paper (scientific journal)
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アンケート調査による脊髄損傷患者の福祉機器の検討 Reviewed
崎濱 智美,帖佐 悦男,濱田 浩朗,久保 紳一郎,黒木 浩史,鳥取部 光司
整形外科と災害外科 54 ( 2 ) 187 - 192 2005.3
Language：Japanese Publishing type：Research paper (scientific journal)
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女性の膝前十字靭帯再建術施行例における術後筋力評価 再建材料による比較 Reviewed
舩元 太郎,帖佐 悦男,園田 典生,山本 惠太郎
整形外科と災害外科 54 ( 2 ) 247 - 250 2005.3
Language：Japanese Publishing type：Research paper (scientific journal)
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ペルテス病にて手術を施行した症例の術前MRIの検討 Reviewed
吉川 大輔,帖佐 悦男,坂本 武郎,渡邊 信二,関本 朝久,濱田 浩朗,前田 和徳
整形外科と災害外科 54 ( 1 ) 162 - 166 2005.3
Language：Japanese Publishing type：Research paper (scientific journal)
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Bucolome, a potent binding inhibitor for furosemide, alters the pharmacokinetics and diuretic effect of furosemide: potential for use of bucolome to restore diuretic response in nephrotic syndrome Reviewed
高村,丸山,帖佐 悦男,河合,堤,う,山崎,出口,小田切
Drug Metab Dispos 33 ( 4 ) 596 - 602 2005.4
Language：English Publishing type：Research paper (scientific journal)
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MISについて思う Reviewed
帖佐 悦男
骨・関節・靭帯 18 ( 4 ) 281 - 282 2005.4
Language：Japanese Publishing type：Research paper (scientific journal)
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股関節撮影-False Profile撮影法（最適な足の位置の研究）- Reviewed
工藤 正喜,牛鼻 健二,押川 美和,下新原 茂,紫垣 誠哉,帖佐 悦男
日本放射線技術学会 61 ( 5 ) 691 - 700 2005.5
Language：Japanese Publishing type：Research paper (scientific journal)
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脊椎手術を施行した透析患者症例の検討 Reviewed
公文 崇詞,黒木 浩史,久保 紳一郎,帖佐 悦男
整形外科と災害外科 54 ( 3 ) 563 - 568 2005.9
Language：Japanese Publishing type：Research paper (scientific journal)
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寛骨臼補正手術（Periacetabular osteotomy)の経験 進行期以降，骨嚢胞（1.5cm以上）症例 Reviewed
帖佐 悦男,坂本 武郎,渡邊 信二,関本 朝久,濱田 浩朗,前田 和徳
Hip Joint 31 56 - 58 2005.10
Language：Japanese Publishing type：Research paper (scientific journal)
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人工関節再置換術におけるCANNULOK Revision Hip Systemの短期成績 Reviewed
坂本 武郎,帖佐 悦男,渡邊 信二,関本 朝久,濱田 浩朗,前田 和徳
Hip Joint 31 624 - 626 2005.10
Language：Japanese Publishing type：Research paper (scientific journal)
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Magnetic resonance imaging evaluation for the preoperative Perthes’ disease. Reviewed
Sekimoto T,Chosa E,Sakamoto T,Watanabe S,Hamada H,Maeda K
31 258 - 261 2005.10
Language：Japanese Publishing type：Research paper (scientific journal)
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骨盤傾斜と股関節症 Hip-spine syndrome Secondary hip-spine syndromeにおける骨盤・脊椎アライメント Reviewed
帖佐 悦男,坂本 武郎,渡邊 信二,前田 和徳,濱田 浩朗,関本 朝久
Hip Joint 31 235 - 238 2005.10
Language：Japanese Publishing type：Research paper (scientific journal)
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Risk factors of failure results after double-bundle reconstruction with autogenous hamstring grafts for isolated posterior cruciate ligament rupture cases Reviewed
Yudai Morita, Takuya Tajima, Nami Yamaguchi, Takuji Yokoe, Makoto Nagasawa, Tomomi Ota, Kouki Ouchi & Etsuo Chosa
Scientific Reports 14 ( 6192 ) 2024.3
Authorship：Last author Language：English Publishing type：Research paper (scientific journal)
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Insertion sites of the muscles attached to the clavicle: a cadaveric study of the clavicle
Imazato H., Takahashi N., Sawaguchi A., Hirakawa Y., Yamaguchi Y., Hiyoshi M., Tajima T., Chosa E.
BMC Musculoskeletal Disorders 24 ( 1 ) 160 2023.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：BMC Musculoskeletal Disorders
Background: Clavicle fractures are common injuries, especially in young, active individuals. Operative treatment is recommended for completely displaced clavicle shaft fractures, and plate fixation is stronger than the use of intramedullary nails. Few studies have reported on iatrogenic injuries to the muscle attached to the clavicle during fracture surgery. The aim of this study was to clarify the area of the insertion sites of muscles attached to the clavicle in Japanese cadavers using gross anatomy and three-dimensional (3D) analysis. We also aimed to compare the effects of anterior plate templating and superior plate templating on clavicle shaft fractures using 3D images. Methods: Thirty-eight clavicles from Japanese cadavers were analyzed. We removed all clavicles to identify the insertion sites and measured the size of the insertion area of each muscle. Three-dimensional templating was performed on both the superior and anterior plates of the clavicle using data obtained from computed tomography. The areas covered by these plates on the muscles attached to the clavicle were compared. Histological examination was performed on four randomly selected specimens. Results: The sternocleidomastoid muscle was attached proximally and superiorly; the trapezius muscle was attached posteriorly and partly superiorly; and the pectoralis major muscle and deltoid muscles were attached anteriorly and partially superiorly. The non-attachment area was located mainly in the posterosuperior part of the clavicle. It was difficult to distinguish the borders of the periosteum and pectoralis major muscles. The anterior plate covered a significantly broader area (mean 6.94 ± 1.36 cm2) of the muscles attached to the clavicle than did the superior plate (mean 4.11 ± 1.52 cm2) (p < 0.0001). On microscopy, these muscles were inserted directly into the periosteum. Conclusion: Most of the pectoralis major and deltoid muscles were attached anteriorly. The non-attachment area was located mainly from the superior to posterior part of the clavicle midshaft. Both macroscopically and microscopically, the boundaries between the periosteum and these muscles were difficult to demarcate. The anterior plate covered a significantly broader area of the muscles attached to the clavicle than that by the superior plate.
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Imazato H., Takahashi N., Hirakawa Y., Yamaguchi Y., Hiyoshi M., Tajima T., Chosa E., Sawaguchi A.
Scientific Reports 13 ( 1 ) 6352 2023.12
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Scientific Reports
Recent physiological studies have shown that the deep fascia has received much attention concerning clinical medicine; however, histological examination of the deep fascia has not been well established. In this study, we aimed to clarify and visualize the structure of the deep fascia by taking advantage of cryofixation techniques and low-vacuum scanning electron microscopy. As a result, the ultrastructural observations revealed three-dimensional stratification of the deep fascia composed of three layers: the first superficial layer consisting of collagen fibers extending in various directions with blood vessels and peripheral nerves; the second intermediate layer formed by single straight and thick collagen fibers with flexibility; and the third deepest layer, consisting of relatively straight and thin collagen fibers. We explored the use of two hooks to hold a piece of deep fascia in place through the course of cryo-fixation. A comparative observation with or without the hook-holding procedure would indicate the morphological adaptation to physiological stretch and contraction of the deep fascia. The present morphological approach paves the way to visualize three-dimensional ultrastructures for future biomedical studies including clinical pathophysiology.
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Tmem161a regulates bone formation and bone strength through the P38 MAPK pathway
Nagai T., Sekimoto T., Kurogi S., Ohta T., Miyazaki S., Yamaguchi Y., Tajima T., Chosa E., Imasaka M., Yoshinobu K., Araki K., Araki M., Choijookhuu N., Sato K., Hishikawa Y., Funamoto T.
Scientific Reports 13 ( 1 ) 14639 2023.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Scientific Reports
Bone remodeling is an extraordinarily complex process involving a variety of factors, such as genetic, metabolic, and environmental components. Although genetic factors play a particularly important role, many have not been identified. In this study, we investigated the role of transmembrane 161a (Tmem161a) in bone structure and function using wild-type (WT) and Tmem161a-depleted (Tmem161aGT/GT) mice. Mice femurs were examined by histological, morphological, and bone strength analyses. Osteoblast differentiation and mineral deposition were examined in Tmem161a-overexpressed, -knockdown and -knockout MC3T3-e1 cells. In WT mice, Tmem161a was expressed in osteoblasts of femurs; however, it was depleted in Tmem161aGT/GT mice. Cortical bone mineral density, thickness, and bone strength were significantly increased in Tmem161aGT/GT mice femurs. In MC3T3-e1 cells, decreased expression of alkaline phosphatase (ALP) and Osterix were found in Tmem161a overexpression, and these findings were reversed in Tmem161a-knockdown or -knockout cells. Microarray and western blot analyses revealed upregulation of the P38 MAPK pathway in Tmem161a-knockout cells, which referred as stress-activated protein kinases. ALP and flow cytometry analyses revealed that Tmem161a-knockout cells were resistant to oxidative stress. In summary, Tmem161a is an important regulator of P38 MAPK signaling, and depletion of Tmem161a induces thicker and stronger bones in mice.
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Tsuruda T., Funamoto T., Suzuki C., Yamamura Y., Nakai M., Chosa E., Kaikita K.
Archives of Osteoporosis 18 ( 1 ) 129 2023.12
Language：English Publishing type：Research paper (scientific journal) Publisher：Archives of Osteoporosis
Purpose: The purpose of this study was to investigate the morphological characteristics of the aortic valve and identify factors associated with the progression of aortic valve stenosis (AS) in osteoporosis patients. Methods: In this single-center prospective cohort study, we recruited 10 patients (mean age: 75 ± 7 years, 90% female) who were taking anti-resorptive medicines at the outpatient clinic of University of Miyazaki Hospital, Japan. Baseline assessments, including transthoracic echocardiogram, blood sampling, and dual energy X-ray absorptiometry, were performed. Follow-up assessments were conducted at 6, 12, 18, and 24 months. Results: During the 2-year follow-up, three patients with aortic valve peak flow velocity (AV PFV) ≥2 m/s at baseline developed moderate AS, which is defined as AV PFV ≥3 m/s. However, seven patients with AV PFV <2 m/s did not exhibit any progression of AS. There were significant variations in terms of bone mineral density, T-score values, and biomarkers associated with bone turnover (i.e., bone alkaline phosphatase, tartrate-resistance acid phosphatase-5b) among the enrolled patients, but none of these factors were found to be associated with the progression of AS. All patients exhibited low vitamin D status, with a median level of 16.1 ng/mL (25th percentile, 9.7 ng/mL; 75th percentile, 23 ng/mL). The baseline levels of AV PFV values were negatively correlated with 25-hydroxyvitamin D levels, determined by univariate linear regression analysis (beta coefficient = -0.756, 95% confidence interval, -0.136 ̶ -0.023, p = 0.011). Conclusion: Our data suggest that low vitamin D status might be a potential risk factor for the progression of AS in osteoporosis patients undergoing treatment with anti-resorptive medicines. Summary : Elderly patients with osteoporosis patients exhibited a subset of aortic valve stenosis. Our data suggest that the baseline aortic valve peak flow velocity predicts the progression of aortic valve stenosis, and there might be an association between the progression and the co-existing low vitamin D status in these patients.
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特集 偽関節治療のエキスパートを目指そう introduction
帖佐 悦男
関節外科 基礎と臨床 42 ( 11 ) 1201 - 1201 2023.11
Publishing type：Research paper (scientific journal) Publisher：メジカルビュー社