Papers - CHOSA Etsuo
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Pharmaceutical Skill Using Displacement of Protein Binding for Pharmacists
TAKAMURA Norito, TOKUNAGA Jin, CHOSA Etsuo, KAWAI Keiichi, FUJITA Ken-ichi, ARIMORI Kazuhiko
YAKUGAKU ZASSHI 127 ( 11 ) 1805 - 1811 2007.11
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：The Pharmaceutical Society of Japan
In pharmacotherapy, to alleviate pains of patients and to provide comforts to patients, pharmacists should improve their pharmaceutical skills of their clinical sense involving pharmaceutical investigational outcomes. Without pharmaceutical skills, pharmacists cannot apply the essence of drug therapies for patients in the most urgent 24 hours treatment. To cope with these drug therapies, we have developed search methods which easily identify the diachronic change of protein binding and the factors in serum (=a new pharmaceutical distribution diagnostic method). This method can speculate diachronic change factors in serum, by monitoring diachronically binding capacities of drug binding sites on human serum albumin (HSA) and α<sub>1</sub>-acid glycoprotein (AGP) molecules in patient sera (add each site probe to each patient serum, and measure the free level of each probe by using TDX/FLX<sup>®</sup> analyzer and HPLC detector), and considering the binding capacities and values of HSA, AGP, free fatty acids, bilirubin (Bil) and blood urea nitrogen (BUN) associating with the amounts of uremic toxins laboratory tests. In addition, the diagnostic method could attempt effective administration by using the protein binding displacement of drugs that have a high protein binding capacity and small distribution volume, or high targeting (=the pharmaceutical skill of protein binding displacement). We have practiced pain control of patients with rheumatoid arthritis by the pharmaceutical skill. It is important for pharmacists to master the pharmaceutical skill in pharmacotherapy.<br>
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[Need for pharmaceutical skill in using displacement of protein binding].
Takamura N, Tokunaga J, Chosa E, Kawai K, Fujita K, Arimori K
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 127 ( 11 ) 1805 - 11 2007.11
Language：Japanese Publishing type：Research paper (scientific journal)
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帖佐 悦男, 山本 惠太郎, 河原 勝博, 園田 典生
臨床スポーツ医学 = The journal of clinical sports medicine 24 ( 10 ) 1057 - 1064 2007.10
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：文光堂
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エビデンスに基づいたアキレス腱断裂の診断手順 Reviewed
帖佐悦男,山本惠太郎,河原勝博,園田典生
臨牀スポーツ医学 24 ( 10 ) 1057 - 1064 2007.10
Language：Japanese Publishing type：Research paper (scientific journal)
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皮切りにこだわらないMIS人工関節置換術 Reviewed
帖佐悦男,坂本武郎,渡邉信二,関本朝久,濱田浩朗,前田和徳,野崎正太郎,中村嘉宏,舩元太郎,柏木輝行
MX人工股関節研究会 2007.7
Language：Japanese Publishing type：Research paper (scientific journal)
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MX-2000ステムの検討 Reviewed
坂本武郎,帖佐悦男,渡邊信二,関本朝久,濱田浩朗,野崎正太郎,前田和徳,中村嘉宏,舩元太郎
MX人工股関節研究会 2007.7
Language：Japanese Publishing type：Research paper (scientific journal)
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河原 勝博, 帖佐 悦男, 鳥取部 光司, 田島 直也
運動療法と物理療法 = The Journal of physical medicine 18 ( 2 ) 2007.6
Language：Japanese Publishing type：Research paper (scientific journal)
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棘突起縦割式脊柱管拡大術の術後成績とHAスペーサーの改良 Reviewed
濱中秀昭, 久保紳一郎, 黒木浩史, 花堂祥治, 桐谷力, 黒木修司, 帖佐悦男
西日本脊椎研究会誌 33 ( 1 ) 29 - 34 2007.6
Language：Japanese Publishing type：Research paper (scientific journal)
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ラグビー競技における宮崎大学式大会安全度評価について ラグビー現場におけるAEDの必要性も含め Reviewed
中村嘉宏, 帖佐悦男, 山本恵太郎, 河原勝博, 田島卓也, 吉川大輔, 吉川教恵
九州・山口スポーツ医・科研究会誌 19 144 - 149 2007.6
Language：Japanese Publishing type：Research paper (scientific journal)
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医学部ラグビー部員引退後の頸椎変化 Reviewed
中村嘉宏, 帖佐悦男, 山本恵太郎, 河原勝博, 田島卓也, 吉川大輔, 吉川教恵
九州・山口スポーツ医・科研究会誌 19 133 - 137 2007.6
Language：Japanese Publishing type：Research paper (scientific journal)
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腰部脊柱管狭窄症に対する顕微鏡視下拡大開窓術の術後成績 Reviewed
桐谷力, 久保紳一郎, 黒木浩史, 濱中秀昭, 花堂祥治, 甲斐糸乃, 帖佐悦男
西日本脊椎研究会誌 33 ( 1 ) 158 - 162 2007.6
Language：Japanese Publishing type：Research paper (scientific journal)
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椎弓根スクリューを用いた頸椎後方固定術の経験 Reviewed
久保紳一郎, 黒木浩史, 花堂祥治, 桐谷力, 黒木修司, 帖佐悦男
西日本脊椎研究会誌 33 ( 1 ) 65 - 70 2007.6
Language：Japanese Publishing type：Research paper (scientific journal)
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3-P2-40 前十字靭帯損傷膝に対する歩行分析(骨関節疾患・運動学運動生理学,ポスター,一般演題,実学としてのリハビリテーションの継承と発展,第44回日本リハビリテーション医学会学術集会)
河原 勝博, 帖佐 悦男, 鳥取部 光司, 濱田 浩朗, 山本 惠太郎
リハビリテーション医学 : 日本リハビリテーション医学会誌 44 ( 0 ) 2007.5
Language：Japanese Publishing type：Research paper (scientific journal) Publisher：社団法人日本リハビリテーション医学会
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特発性側弯症患者における装具装着状況の検討 Reviewed
黒木浩史，久保紳一郎，帖佐悦男，田島直也
脊柱変形 22 42 - 46 2007.4
Language：Japanese Publishing type：Research paper (scientific journal)
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Treatment of Giant Bone Defect for Osteofibrous Dysplasia with Only β-TCP:3 Case Reports Reviewed
Orthopedics & Traumatology 56 ( 3 ) 458 - 461 2007.4
Language：Japanese Publishing type：Research paper (scientific journal)
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薬剤師が"薬術"を獲得することの重要性 : 薬学的分布診断法（血清内探索法）と攻めの薬物投与法
髙村 徳人,德永 仁,帖佐 悦男,川井 恵一,有森 和彦,大井 一弥
医薬ジャーナル 43 ( 3 ) 963 - 973 2007.3
Language：Japanese Publishing type：Research paper (scientific journal)
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Revision arthroplasties for rhematoid knee Reviewed
Koichiro Saisho, Hideho Uchida, Hiroshi Murakami, Yuich Arizumi, Tsuyoshi Enatsu, Koji Totoribe, Etsuo Chosa
Kyushu Rheumatology 26 ( 2 ) 96 - 101 2007.3
Language：Japanese Publishing type：Research paper (scientific journal)
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税所 幸一郎,内田 秀穂,村上 弘,有住 裕一,鳥取部 光司,帖佐 悦男
九州リウマチ 26 ( 2 ) 96 - 101 2006.12
Language：Japanese Publishing type：Research paper (scientific journal)
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Effect on the sagittal alignment of the brace treatment for idiopathic scoliosis
KUROKI Hiroshi
21 ( 1 ) 50 - 55 2006.12
Language：Japanese Publishing type：Research paper (scientific journal)
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YAMAMOTO Keitaro, CHOSA Etsuo, KOMATSU Nami
31 ( 3 ) 165 - 170 2006.10
Language：Japanese Publishing type：Research paper (scientific journal)